诱变中的错误以及细胞间信号传导在应激诱导诱变进化中的益处。
Errors in mutagenesis and the benefit of cell-to-cell signalling in the evolution of stress-induced mutagenesis.
作者信息
Dellus-Gur Eynat, Ram Yoav, Hadany Lilach
机构信息
Department of Molecular Biology and Ecology of Plants, Tel-Aviv University, Tel-Aviv 69978, Israel.
出版信息
R Soc Open Sci. 2017 Nov 1;4(11):170529. doi: 10.1098/rsos.170529. eCollection 2017 Nov.
Stress-induced mutagenesis is a widely observed phenomenon. Theoretical models have shown that stress-induced mutagenesis can be favoured by natural selection due to the beneficial mutations it generates. These models, however, assumed an error-free regulation of mutation rate in response to stress. Here, we explore the effects of errors in the regulation of mutagenesis on the evolution of stress-induced mutagenesis, and consider the role of cell-to-cell signalling. Using theoretical models, we show (i) that stress-induced mutagenesis can be disadvantageous if errors are common; and (ii) that cell-to-cell signalling can allow stress-induced mutagenesis to be favoured by selection even when error rates are high. We conclude that cell-to-cell signalling can facilitate the evolution of stress-induced mutagenesis in microbes through second-order selection.
应激诱导的诱变是一种广泛观察到的现象。理论模型表明，由于应激诱导的诱变所产生的有益突变，自然选择可能会青睐它。然而，这些模型假定了在应激反应中突变率的无误差调节。在这里，我们探讨诱变调节中的误差对应激诱导诱变进化的影响，并考虑细胞间信号传导的作用。使用理论模型，我们表明：（i）如果误差普遍存在，应激诱导的诱变可能是不利的；（ii）即使错误率很高，细胞间信号传导也可以使应激诱导的诱变受到选择的青睐。我们得出结论，细胞间信号传导可以通过二阶选择促进微生物中应激诱导诱变的进化。
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