Almas Iqra, Afzal Samia, Idrees Muhammad, Ashraf Muhammad Usman, Amin Iram, Shahid Muhammad, Zahid Khadija, Zahid Sadia
Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Hazara University, Mansehra, KPK Pakistan.
Virusdisease. 2017 Dec;28(4):360-367. doi: 10.1007/s13337-017-0407-3. Epub 2017 Nov 27.
Hepatitis C virus (HCV) is associated with one of the major health problem in world that ultimate results in the liver cirrhosis and leads to carcinoma of hepatocellular components round the world. More than 185 million people were found to be infected with HCV. MicroRNAs are small oligonucleotide RNA having 18-22 nucleotides. Circulating mi-RNAs regulate the replication of HCV and HCV-induced liver fibrosis and HCC. By comparing the expression profiles of mi-RNAs of normal individuals with HCV infected patients, aberrant changes in expression of different mi-RNAs have been observed so it can be predicted that these mi-RNAs are associated with and play a central role in the hepatitis C infection and diseases associated with it. This review demonstrates the major role of circulatory microRNAs in the HCV and HCV associated ailments.
丙型肝炎病毒（HCV）与全球主要健康问题之一相关，最终会导致肝硬化并引发世界各地的肝细胞癌。已发现超过1.85亿人感染了HCV。微小RNA是具有18 - 22个核苷酸的小寡核苷酸RNA。循环中的微小RNA调节HCV的复制以及HCV诱导的肝纤维化和肝癌。通过比较正常个体与HCV感染患者的微小RNA表达谱，已观察到不同微小RNA表达的异常变化，因此可以预测这些微小RNA与丙型肝炎感染及其相关疾病有关并在其中发挥核心作用。本综述阐述了循环微小RNA在HCV及HCV相关疾病中的主要作用。
