Aberg N, Engström I, Lindberg U
Department of Paediatrics I, Gothenburg University, Sweden.
Acta Paediatr Scand. 1989 Mar;78(2):246-52. doi: 10.1111/j.1651-2227.1989.tb11064.x.
The occurrence of allergic diseases in children was studied on the basis of a questionnaire sent to the parents of 20,000 school children, 7, 10 and 14 years of age, in 3 parts of Sweden with different climatic conditions. The prevalence of asthma was 2.4%, allergic rhinoconjunctivitis 7.4%, eczema 7.8% and total allergic diseases 16.9%. The prevalence of all diseases was significantly higher in the northern part of the country than in the southern parts. This geographic variation was not related to heredity, infant feeding pattern or known exposure variables other than the cold and dry climate. Parental history of allergic diseases increased the incidence in the offspring 2-9 times, with a pattern of symptom specificity and a cumulative effect of double parental history. Breast-feeding postponed the onset of allergic disease only in children with double parental history.
基于向瑞典3个气候条件不同地区的20000名7岁、10岁和14岁学童的家长发放的调查问卷,对儿童过敏性疾病的发生情况进行了研究。哮喘的患病率为2.4%,过敏性鼻结膜炎为7.4%,湿疹为7.8%,过敏性疾病总患病率为16.9%。该国北部所有疾病的患病率显著高于南部。这种地理差异与遗传、婴儿喂养方式或除寒冷干燥气候外的已知暴露变量无关。父母有过敏性疾病史会使后代的发病率增加2至9倍,具有症状特异性模式以及双亲均有病史的累积效应。母乳喂养仅在双亲均有病史的儿童中推迟了过敏性疾病的发病。