急性颅内高压期间下丘脑 - 垂体抗利尿系统激活与利尿类型之间的分离。实验观察
Dissociation between activation of the hypothalamo-hypophyseal antidiuretic system and the type of diuresis during acute intracranial hypertension. Experimental observation.
作者信息
Rap Z M, Koca M, Hildebrandt G, Mueller H W, Pia H W
机构信息
Neurosurgical Clinic, University of Giessen, Federal Republic of Germany.
出版信息
Acta Neurochir (Wien). 1989;96(1-2):63-71. doi: 10.1007/BF01403496.
Acute cerebral compression by a supra- and infratentorial balloon produced a triphasic pattern of diuresis. The 1st phase was characterized by polyuria associated with five fold increase of plasma (p) antidiuretic hormone (ADH) concentration, decreased urine osmolality in spite of natriuresis and blood pressure elevation. The 2nd phase was characterized by oliguria, a decrease of pADH and reduced urine Na+ concentration, whereas urine osmolality transiently increased. At this stage there was respiratory arrest and fall of blood pressure. The final stage was diabetes insipidus (DI), when EEG activity had disappeared. An increase of serum osmolality mainly occurred during the last DI phase. Serum Na+ concentration fluctuated slightly during the whole period of diuresis. These results present evidence, that the diuresis pattern reflects the hypothalamo-hypophyseal antidiuretic system (HHAS) reaction to acute intracranial pressure (ICP) increase with the vegetative symptoms of cerebral shock.
幕上和幕下气囊导致的急性脑受压产生了三相利尿模式。第一阶段的特征是多尿，伴有血浆抗利尿激素（ADH）浓度增加五倍，尽管有钠利尿和血压升高，但尿渗透压降低。第二阶段的特征是少尿、血浆ADH降低和尿钠浓度降低，而尿渗透压短暂升高。在此阶段出现呼吸骤停和血压下降。最后阶段是尿崩症（DI），此时脑电图活动消失。血清渗透压升高主要发生在最后的DI阶段。在整个利尿期，血清钠浓度略有波动。这些结果表明，利尿模式反映了下丘脑 - 垂体抗利尿系统（HHAS）对急性颅内压（ICP）升高的反应以及脑休克的自主症状。
Zotero 插件