von Bormann B, Weidler B, Dennhardt R, Frings N, Lennartz H, Hempelmann G
Anasth Intensivther Notfallmed. 1981 Dec;16(6):319-22.
For a period of five days serum levels of antidiuretic hormone (ADH) have been investigated postoperatively in a group of 20 patients with upper abdominal surgery. In addition serum electrolytes (Na+, K+) and plasma osmolality have been controlled regularly. Patients in group A (n = 10) received Fentanyl epidurally (0.1-0.2 mg diluted with 0.9% saline solution) for treatment of postoperative pain, whereas in group B (n = 10) systemic opiate therapy was performed by intramuscular application of piritramide (Dipidolor, 15-25 mg). There was a significant increase in ADH in all patients, whereas serum electrolytes (Na+, K+) and plasma osmolality stayed within normal range. ADH-levels in group A (epidural opiate), however, were significantly lower than mean values in group B (systemic opiate application). The postoperative increase in ADH is interpreted as a reaction to stress and trauma, being less pronounced, when epidural opiate therapy is performed for postoperative pain treatment.
对20例接受上腹部手术的患者术后连续5天进行了抗利尿激素（ADH）血清水平的研究。此外，还定期监测血清电解质（Na +、K +）和血浆渗透压。A组（n = 10）患者通过硬膜外给予芬太尼（0.1 - 0.2 mg用0.9%盐水溶液稀释）治疗术后疼痛，而B组（n = 10）患者通过肌肉注射匹利卡明（地匹哌酮，15 - 25 mg）进行全身阿片类药物治疗。所有患者的ADH均显著升高，而血清电解质（Na +、K +）和血浆渗透压保持在正常范围内。然而，A组（硬膜外使用阿片类药物）的ADH水平显著低于B组（全身使用阿片类药物）的平均值。术后ADH的升高被解释为对压力和创伤的反应，当采用硬膜外阿片类药物治疗术后疼痛时，这种反应不太明显。
