Imperial College London, London, UK.
University of Oxford, Oxford, UK.
J Exp Bot. 2018 Mar 14;69(6):1325-1333. doi: 10.1093/jxb/erx425.
In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens, regulating plant cell death, and antimicrobial defences. In turn, it appears that phytopathogens have evolved ways not only to evade autophagic clearance but also to modulate and co-opt autophagy for their own benefit. In this review, we summarize and discuss the emerging discoveries concerning how pathogens modulate both host and self-autophagy machineries to colonize their host plants, delving into the arms race that determines the fate of interorganismal interaction.
在植物中,自噬这一高度保守的分解代谢过程一直被认为是维持细胞内稳态和应对非生物胁迫条件的一种手段。越来越多的证据表明,自噬与植物对入侵病原体的免疫反应有关,它可以调节植物细胞死亡和抗菌防御。反过来,植物病原体似乎也进化出了不仅逃避自噬清除,而且还调节和篡夺自噬以谋取自身利益的方法。在这篇综述中,我们总结并讨论了关于病原体如何调节宿主和自身自噬机制以定殖宿主植物的新发现,深入探讨了决定种间相互作用命运的军备竞赛。