Center for Plant Biology, Tsinghua-Peking Joint Center for Life Sciences, MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Center for Plant Biology, Tsinghua-Peking Joint Center for Life Sciences, MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Semin Cell Dev Biol. 2020 May;101:36-40. doi: 10.1016/j.semcdb.2019.07.001. Epub 2019 Jul 10.
Autophagy is an essential and conserved cellular degradation pathway in eukaryotes. In metazoans, autophagy is highly engaged during the immune responses through interfacing either directly with intracellular pathogens or indirectly with immune signaling molecules. Recent studies have demonstrated that autophagy plays important roles in regulating immunity-related cell death, antiviral and promoting viral pathogenesis during plant-virus interactions. In this review, we will summarize latest progresses and discuss the significant roles of autophagy in the defense and counter-defense arm race between host plants and viruses.
自噬是真核生物中一种必不可少且保守的细胞降解途径。在后生动物中,自噬在免疫反应中高度活跃,直接与细胞内病原体相互作用,或间接与免疫信号分子相互作用。最近的研究表明,自噬在调控免疫相关细胞死亡、抗病毒以及促进植物-病毒相互作用中的病毒发病机制方面发挥着重要作用。在这篇综述中,我们将总结最新进展,并讨论自噬在宿主植物和病毒之间的防御和反防御军备竞赛中的重要作用。