Hofius Daniel, Li Liang, Hafrén Anders, Coll Nuria S
Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center of Plant Biology, SE-75007 Uppsala, Sweden.
Centre for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB), Bellaterra-Cerdanyola del Valles, 08193 Catalonia, Spain.
Curr Opin Plant Biol. 2017 Aug;38:117-123. doi: 10.1016/j.pbi.2017.04.017. Epub 2017 May 22.
Autophagy is a highly conserved degradation and recycling process that controls cellular homeostasis, stress adaptation, and programmed cell death in eukaryotes. Emerging evidence indicates that autophagy is a key regulator of plant innate immunity and contributes with both pro-death and pro-survival functions to antimicrobial defences, depending on the pathogenic lifestyle. In turn, several pathogens have co-opted and evolved strategies to manipulate host autophagy pathways to the benefit of infection, while some eukaryotic microbes require their own autophagy machinery for successful pathogenesis. In this review, we present and discuss recent advances that exemplify the important role of pro- and antimicrobial autophagy in plant-pathogen interactions.
自噬是一种高度保守的降解和循环利用过程，它控制着真核生物中的细胞内稳态、应激适应和程序性细胞死亡。新出现的证据表明，自噬是植物先天免疫的关键调节因子，根据致病生活方式的不同，它在抗菌防御中具有促死亡和促存活功能。反过来，一些病原体已经采用并进化出策略来操纵宿主自噬途径以利于感染，而一些真核微生物则需要它们自己的自噬机制来成功致病。在这篇综述中，我们展示并讨论了最近的进展，这些进展例证了促自噬和抗菌自噬在植物-病原体相互作用中的重要作用。
