Ji Yuelong, Riley Anne W, Lee Li-Ching, Volk Heather, Hong Xiumei, Wang Guoying, Angomas Rayris, Stivers Tom, Wahl Anastacia, Ji Hongkai, Bartell Tami R, Burd Irina, Paige David, Fallin Margaret D, Zuckerman Barry, Wang Xiaobin
Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Brain Sci. 2017 Dec 23;8(1):3. doi: 10.3390/brainsci8010003.
Growing evidence suggests that maternal cholesterol levels are important in the offspring's brain growth and development. Previous studies on cholesterols and brain functions were mostly in adults. We sought to examine the prospective association between maternal cholesterol levels and the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. We analyzed data from the Boston Birth Cohort, enrolled at birth and followed from birth up to age 15 years. The final analyses included 1479 mother-infant pairs: 303 children with ADHD, and 1176 neurotypical children without clinician-diagnosed neurodevelopmental disorders. The median age of the first diagnosis of ADHD was seven years. The multiple logistic regression results showed that a low maternal high-density lipoprotein level (≤60 mg/dL) was associated with an increased risk of ADHD, compared to a higher maternal high-density lipoprotein level, after adjusting for pertinent covariables. A "J" shaped relationship was observed between triglycerides and ADHD risk. The associations with ADHD for maternal high-density lipoprotein and triglycerides were more pronounced among boys. The findings based on this predominantly urban low-income minority birth cohort raise a new mechanistic perspective for understanding the origins of ADHD and the gender differences and future targets in the prevention of ADHD.
越来越多的证据表明，母体胆固醇水平对后代的大脑生长和发育至关重要。先前关于胆固醇与脑功能的研究大多针对成年人。我们试图研究母体胆固醇水平与后代注意力缺陷多动障碍（ADHD）风险之间的前瞻性关联。我们分析了波士顿出生队列的数据，该队列在出生时入组，并从出生一直随访到15岁。最终分析纳入了1479对母婴：303名患有ADHD的儿童，以及1176名无临床诊断神经发育障碍的神经典型儿童。ADHD首次诊断的中位年龄为7岁。多元逻辑回归结果显示，在调整相关协变量后，与较高的母体高密度脂蛋白水平相比，低母体高密度脂蛋白水平（≤60mg/dL）与ADHD风险增加相关。在甘油三酯与ADHD风险之间观察到一种“J”形关系。母体高密度脂蛋白和甘油三酯与ADHD的关联在男孩中更为明显。基于这个主要由城市低收入少数族裔组成的出生队列的研究结果，为理解ADHD的起源、性别差异以及ADHD预防的未来目标提出了一个新的机制视角。
