Department of Environmental Sciences, Faculty of Meteorology, Environment and Arid Land Agriculture, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Center of Excellence in Environmental Studies, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Int J Environ Res Public Health. 2017 Dec 25;15(1):27. doi: 10.3390/ijerph15010027.
Recent epidemiological evidence suggests that exposure to particulates may be a factor in the etiology of metabolic syndrome (MetS). In this novel study, we investigated the relationship between particulate levels and prevalence of MetS component abnormalities (hypertension, hyperglycemia, obesity) in a recruited cohort (N = 2025) in Jeddah, Saudi Arabia. We observed significant associations between a 10 μg/m³ increase in PM and increased risks for MetS (Risk Ratio (RR): 1.12; 95% Confidence Interval (CI): 1.06-1.19), hyperglycemia (RR: 1.08; 95% CI: 1.03-1.14), and hypertension (RR: 1.09; 95% CI: 1.04-1.14). PM from soil/road dust was found to be associated with hyperglycemia (RR: 1.12; 95% CI: 1.06-1.19) and hypertension (RR: 1.11; 95% CI: 1.05-1.18), while PM from traffic was associated with hyperglycemia (RR: 1.33; 95% CI: 1.05-1.71). We did not observe any health associations with source-specific mass exposures. Our findings suggest that exposure to specific elemental components of PM, especially Ni, may contribute to the development of cardiometabolic disorders.
最近的流行病学证据表明，颗粒物暴露可能是代谢综合征（MetS）病因学的一个因素。在这项新的研究中，我们调查了沙特阿拉伯吉达招募队列（N=2025）中颗粒物水平与 MetS 成分异常（高血压、高血糖、肥胖）患病率之间的关系。我们观察到 PM 每增加 10μg/m³，MetS（风险比 (RR)：1.12；95%置信区间 (CI)：1.06-1.19）、高血糖症（RR：1.08；95% CI：1.03-1.14）和高血压（RR：1.09；95% CI：1.04-1.14）的风险显著增加。土壤/道路灰尘来源的 PM 被发现与高血糖症（RR：1.12；95% CI：1.06-1.19）和高血压（RR：1.11；95% CI：1.05-1.18）相关，而交通来源的 PM 与高血糖症相关（RR：1.33；95% CI：1.05-1.71）。我们没有观察到任何与特定来源质量暴露相关的健康关联。我们的研究结果表明，暴露于 PM 的特定元素成分，特别是 Ni，可能导致心血管代谢紊乱的发生。
