Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, PR China.
Department of Occupation Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, PR China.
Sci Total Environ. 2021 Aug 15;782:146855. doi: 10.1016/j.scitotenv.2021.146855. Epub 2021 Apr 1.
Although the association between ambient particulate matter and metabolic syndrome (MetS) has been investigated, the effect of particulate matter (PM) on MetS is inconclusive. We conducted a systematic review and meta-analysis to study the association between long-term ambient PM exposure and MetS risk. The data from five databases were extracted to analyze the association between ambient PM exposure and MetS risk. A random-effects model was performed to estimate the overall risk effect. The present systematic review and meta-analysis illustrated that an increase of 5 μg/m in annual PM or PM concentration was associated with 14% or 9% increases of MetS risk, respectively (PM, RR = 1.14, 95%CI [1.03, 1.25]; PM, RR = 1.09, 95%CI [1.00, 1.19]). The population-attributable risk (PAR) was 12.28% for PM exposure or 8.26% for PM exposure, respectively. There was statistical association between PM exposure and risk of MetS in male proportion ≥50%, Asia, related disease or medication non-adjustment subgroup as well as cohort study subgroups, respectively. The significant association between PM exposure and risk of MetS was observed in male proportion ≥50% and calories intake adjustment subgroups, respectively. Sensitivity analyses showed the robustness of our results. No publication bias was detected. In conclusion, there was positive association between long-term PM exposure and MetS risk. 12.28% of MetS risk could be attributable to PM exposure.
虽然环境颗粒物与代谢综合征（MetS）之间的关联已被研究过，但颗粒物（PM）对 MetS 的影响尚无定论。我们进行了一项系统评价和荟萃分析，以研究长期环境 PM 暴露与 MetS 风险之间的关系。从五个数据库中提取数据来分析环境 PM 暴露与 MetS 风险之间的关联。采用随机效应模型来估计总体风险效应。本系统评价和荟萃分析表明，每年 PM 或 PM 浓度增加 5μg/m 与 MetS 风险增加 14%或 9%相关（PM，RR=1.14，95%CI[1.03，1.25]；PM，RR=1.09，95%CI[1.00，1.19]）。PM 暴露的人群归因风险（PAR）为 12.28%，PM 暴露的 PAR 为 8.26%。在男性比例≥50%、亚洲、相关疾病或未调整药物亚组以及队列研究亚组中，PM 暴露与 MetS 风险之间存在统计学关联。在男性比例≥50%和热量摄入调整亚组中，PM 暴露与 MetS 风险之间存在显著关联。敏感性分析表明我们的结果具有稳健性。未发现发表偏倚。总之，长期 PM 暴露与 MetS 风险之间存在正相关。12.28%的 MetS 风险可归因于 PM 暴露。
