1 eCampus University, Novedrate, Italy.
2 Assisted Health Residence "Ville Roddolo," Moncalieri, Italy.
J Appl Gerontol. 2019 Jul;38(7):1035-1044. doi: 10.1177/0733464817750276. Epub 2018 Jan 2.
We investigated the stability of effects of a computerized cognitive training previously administered to a large group of early stage Alzheimer's disease (AD) patients, as compared with a control group.
Eighty AD patients were randomized in two groups and underwent a computerized cognitive training, or a control intervention.
A Repeated Measures General Linear Model (RM-GLM) showed a significant interaction effect for the following neuropsychological tests: the digit span forward and backward, and the two-syllable words test, as measures of short-term memory and working memory; the Rivermead Behavioural Memory Test (RBMT) story immediate and the RBMT story delayed, as measures of ecologically oriented memory; the Token test, as measure of language comprehension; and the Brixton test, as an executive functions measure.
Patients in the experimental group showed a significant improvement in various neuropsychological domains due to the training, and these effects decreased after 12 months.
我们研究了先前对一大群早期阿尔茨海默病（AD）患者进行的计算机认知训练的效果稳定性，与对照组进行了比较。
80 名 AD 患者随机分为两组，分别接受计算机认知训练或对照组干预。
重复测量一般线性模型（RM-GLM）显示以下神经心理学测试存在显著的交互效应：数字跨度前向和后向，以及双音节词测试，作为短期记忆和工作记忆的测量；Rivermead 行为记忆测试（RBMT）故事即时和 RBMT 故事延迟，作为生态导向记忆的测量；代币测试，作为语言理解的测量；以及 Brixton 测试，作为执行功能的测量。
实验组患者由于训练而在各个神经心理学领域显著改善，并且这些效果在 12 个月后下降。
