Yau Y, Zeighami Y, Baker T E, Larcher K, Vainik U, Dadar M, Fonov V S, Hagmann P, Griffa A, Mišić B, Collins D L, Dagher A
Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ, 07102, USA.
Nat Commun. 2018 Jan 2;9(1):12. doi: 10.1038/s41467-017-02416-0.
Here we test the hypothesis that the neurodegenerative process in Parkinson's disease (PD) moves stereotypically along neural networks, possibly reflecting the spread of toxic alpha-synuclein molecules. PD patients (n = 105) and matched controls (n = 57) underwent T1-MRI at entry and 1 year later as part of the Parkinson's Progression Markers Initiative. Over this period, PD patients demonstrate significantly greater cortical thinning than controls in parts of the left occipital and bilateral frontal lobes and right somatomotor-sensory cortex. Cortical thinning is correlated to connectivity (measured functionally or structurally) to a "disease reservoir" evaluated by MRI at baseline. The atrophy pattern in the ventral frontal lobes resembles one described in certain cases of Alzheimer's disease. Our findings suggest that disease propagation to the cortex in PD follows neuronal connectivity and that disease spread to the cortex may herald the onset of cognitive impairment.
在此，我们检验这样一种假设：帕金森病（PD）中的神经退行性过程沿着神经网络刻板地进展，这可能反映了有毒α-突触核蛋白分子的扩散。作为帕金森病进展标志物倡议的一部分，105例PD患者和57例匹配对照在入组时及1年后接受了T1加权磁共振成像（MRI）检查。在此期间，PD患者在左侧枕叶、双侧额叶部分区域及右侧躯体运动感觉皮层的皮质变薄程度显著大于对照组。皮质变薄与通过基线MRI评估的与“疾病储备区”的连接性（通过功能或结构测量）相关。腹侧额叶的萎缩模式类似于某些阿尔茨海默病病例中所描述的情况。我们的研究结果表明，PD中疾病向皮质的传播遵循神经元连接性，并且疾病向皮质的扩散可能预示着认知障碍的 onset。（注：原文中onset未翻译完整，推测是“发作”之类的意思，可根据完整语义进行调整）
