Zhang Rui-Li, Zhang Xia, Dong Shan-Shan, Hu Bing, Han Qiu-Yue, Zhang Jian-Gang, Zhou Wen-Jun, Lin Aifen, Yan Wei-Hua
Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, P.R. China.
Human Tissue Bank, Wenzhou Medical University affiliated Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, P.R. China.
Oncotarget. 2017 Nov 18;8(64):107441-107451. doi: 10.18632/oncotarget.22487. eCollection 2017 Dec 8.
Differential expression of HLA-G has been observed among cancer types and tumors from individuals with the same type of cancer; however, its clinical significance is rather limited. In this study, expression and predictive relevance of HLA-G expression in 457 primary colorectal cancer (CRC, n = 232, n = 225) patients was investigated. Data showed 70.7% (323/457) of the CRC were HLA-G expression when the above 5% (HLA-G) was considered as positive, which wasn't associated with patient survival ( = 0.109). However, HLA-G expression above 55% (HLA-G) was associated with a worse prognosis of CRC patients ( = 0.042). Furthermore, a shorter survival was found for the female ( = 0.042) and elder ( = 0.037) patients whose HLA-G expression was above HLA-G level. HLA-G expression above HLA-G level showed a worse prognosis for female ( = 0.013), elder ( = 0.023), colon cancer ( = 0.016), advanced tumor burden (T, = 0.018), regional lymph node status (N, = 0.044), and advanced clinical stage patients (AJCC , = 0.037). In conclusion, our results demonstrated for the first time that combination of differential lesion HLA-G expression notably improved the value of traditional survival prediction for CRC patients.
在不同癌症类型以及同一类型癌症患者的肿瘤之间，已观察到HLA - G的差异表达；然而，其临床意义相当有限。在本研究中，调查了457例原发性结直肠癌（CRC，n = 232，n = 225）患者中HLA - G表达及其预测相关性。数据显示，当将上述5%（HLA - G）视为阳性时，70.7%（323/457）的CRC存在HLA - G表达，这与患者生存率无关（P = 0.109）。然而，HLA - G表达高于55%（HLA - G）与CRC患者预后较差相关（P = 0.042）。此外，发现HLA - G表达高于HLA - G水平的女性（P = 0.042）和老年患者（P = 0.037）生存期较短。HLA - G表达高于HLA - G水平在女性（P = 0.013）、老年患者（P = 0.023）、结肠癌（P = 0.016）、肿瘤负荷晚期（T，P = 0.018）、区域淋巴结状态（N，P = 0.044）以及临床分期晚期（AJCC，P = 0.037）患者中显示出较差的预后。总之，我们的结果首次证明，差异病变HLA - G表达的联合显著提高了CRC患者传统生存预测的价值。
