伊朗阿瓦士儿科医疗中心的菌种流行率及抗菌药物耐药模式研究。
A Study of prevalence of species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran.
作者信息
Nikfar Roya, Shamsizadeh Ahmad, Darbor Marjan, Khaghani Soheila, Moghaddam Mina
机构信息
Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Pediatrics, Aboozar Children's Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Iran J Microbiol. 2017 Oct;9(5):277-283.
BACKGROUND AND OBJECTIVES
infections are one of the major causes of diarrhea worldwide, and especially in developing countries. Antimicrobial resistance has complicated the empirical treatment. The aim of this study was to define the clinical and antibiotic resistance patterns of gastroenteritis cases.
MATERIALS AND METHODS
Stool samples of patients with diarrhea and fever diagnosed with shigellosis were collected, from June 2013 to May 2014 at Abuzar Hospital, Iran. All samples were cultured for spp on selective and differential media. isolates were evaluated for antimicrobial resistance.
RESULTS
Among 193 isolates, (64.8%) was the predominant species followed by (32.6%). The most frequent antibiotic resistance observed, was towards co-trimoxazole (89%), ampicillin (77%) and ceftriaxone (51%) and the lowest resistance were seen in ciprofloxacin (1.5%), azithromycin (7%).
CONCLUSION
Due to the high resistance to ceftriaxone, this drug is not recommended as an empirical therapy for shigellosis. However, azithromycin should be used as the first-line treatment for paediatric patients, suffering from shigellosis and ciprofloxacin can be used as an alternative.
背景与目的
感染是全球腹泻的主要原因之一，在发展中国家尤为如此。抗生素耐药性使经验性治疗变得复杂。本研究的目的是确定胃肠炎病例的临床和抗生素耐药模式。
材料与方法
2013年6月至2014年5月在伊朗阿布扎尔医院收集诊断为志贺菌病的腹泻和发热患者的粪便样本。所有样本在选择性和鉴别培养基上培养志贺菌属。对分离株进行抗生素耐药性评估。
结果
在193株分离株中，宋内志贺菌（64.8%）是主要菌种，其次是福氏志贺菌（32.6%）。观察到的最常见抗生素耐药性是对复方新诺明（89%）、氨苄青霉素（77%）和头孢曲松（51%），而对环丙沙星（1.5%）、阿奇霉素（7%）的耐药性最低。
结论
由于对头孢曲松的高耐药性，不推荐将该药物作为志贺菌病的经验性治疗药物。然而，阿奇霉素应作为患有志贺菌病的儿科患者的一线治疗药物，环丙沙星可作为替代药物。
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