Jomezadeh Nabi, Babamoradi Shahram, Kalantar Enayatollah, Javaherizadeh Hazhir
Abadan School of Medical Sciences, Abadan, Iran.
Ilam University of Medical Sciences, Ilam, Iran.
Gastroenterol Hepatol Bed Bench. 2014 Fall;7(4):218-23.
The aim of this study was to determine the incidence of Shigella species and their antimicrobial susceptibility patterns in hospitalized children with Shigellosis in Abadan, Iran.
Shigellosis is caused by different species of Shigella and one of the most common causes of diarrhea in children. This disease is endemic in many developing countries including Iran.
This prospective cross sectional study was conducted in a teaching hospital in Abadan, Iran during June 2011 to May 2013. Stool specimens were collected from pediatric age group. All isolates were confirmed as Shigella species by biochemical and serologic tests. Antibiotic sensitivity pattern of these isolates was studied by disk diffusion Method.
Among all 705 stool samples, 36 (5.1%) yielded Shigella. Of cases, 392 (55.6%) were girl and 313 (44.4%) were boy. The most common Shigella isolates were S. flexneri (n=19, 52.7%) followed by S. sonnei (n=11, 30.5%), S. boydii (n=4, 11.1%) and S. dysenteriae 2(5.5%). Of the Shigella isolates, 47.2% showed resistance to two or more antimicrobial agents. Resistance pattern against various antimicrobials were as follows: trimethoprim-sulphamethoxazole (80.5%), ampicillin (63.8%), tetracycline (58.3%), chloramphenicol (33.3%), nalidixic acid (27.7%), and cefixime (16.6%). There was no resistance against ciprofloxacin and ceftriaxone.
The most common isolates were S. flexneri followed by S. Sonnei. There was no antibiotic resistance against ciprofloxacin and ceftriaxone. TMP-SMZ showed highest resistance pattern.
本研究旨在确定伊朗阿巴丹地区住院志贺菌病患儿中志贺菌属的发病率及其抗菌药物敏感性模式。
志贺菌病由不同种类的志贺菌引起，是儿童腹泻最常见的病因之一。该病在包括伊朗在内的许多发展中国家呈地方性流行。
本前瞻性横断面研究于2011年6月至2013年5月在伊朗阿巴丹的一家教学医院进行。从儿童年龄组采集粪便标本。所有分离株均通过生化和血清学试验确认为志贺菌属。采用纸片扩散法研究这些分离株的抗生素敏感性模式。
在所有705份粪便样本中，36份（5.1%）检出志贺菌。病例中，女孩392例（55.6%），男孩313例（44.4%）。最常见的志贺菌分离株是福氏志贺菌（n=19，52.7%），其次是宋内志贺菌（n=11，30.5%）、鲍氏志贺菌（n=4，11.1%）和痢疾志贺菌2型（5.5%）。在志贺菌分离株中，47.2%对两种或更多抗菌药物耐药。对各种抗菌药物的耐药模式如下：复方新诺明（80.5%）、氨苄西林（63.8%）、四环素（58.3%）、氯霉素（33.3%）、萘啶酸（27.7%）和头孢克肟（16.6%）。对环丙沙星和头孢曲松无耐药。
最常见的分离株是福氏志贺菌，其次是宋内志贺菌。对环丙沙星和头孢曲松无抗生素耐药。复方新诺明显示出最高的耐药模式。
