Primary intraparenchymal brain melanoma: a case report.

Primary intraparenchymal brain melanocytic lesions are very rare and arise from leptomeninges in the superficial cortex with invariably poor clinical outcome. We report a case of a 45-year old male who presented with an intraparenchymal brain lesion without meningeal involvement, radiologicallly consistent with primary brain tumor. However, the pathology of excisional biopsy proved to be melanoma on histopathology and immunohistochemistry. Treatment consisted of limited surgery followed by local radiotherapy with the patient had no significant clinical improvement, and was managed conservatively with steroids along with chemotherapy. The patient died due to diffuse intracranial dissemination within 4 months from completion of radiotherapy.