Yamane K, Shima T, Okada Y, Nishida M, Okita S, Hatayama T, Nishida T
Department of Neurosurgery, Chugoku Rousai Hospital, Hiroshima, Japan.
Surg Neurol. 1994 Nov;42(5):433-7. doi: 10.1016/0090-3019(94)90353-0.
A rare case of primary pineal melanoma is reported. The patient was a 53-year-old woman who complained of a severe headache. Computed tomography and magnetic resonance images revealed obstructive hydrocephalus caused by a mass lesion in the pineal region. A biopsy was performed through an occipital transtentorial approach. A black pigmented solitary tumor was seen without leptomeningeal dissemination. Histologic examination revealed melanoma. Chemotherapy consisting of dacarbazine, ACNU, vincristine, and interferon was used. Follow-up imaging studies showed dramatic reduction of the tumor without recurrence for 4 years. This report demonstrates that a solitary primary intracranial melanoma without leptomeningeal dissemination and with rare mitoses may yield a good result with chemotherapy.
报告了一例罕见的原发性松果体黑色素瘤病例。患者为一名53岁女性，主诉严重头痛。计算机断层扫描和磁共振成像显示松果体区肿块病变导致梗阻性脑积水。通过枕下经小脑幕入路进行了活检。可见一个黑色色素沉着的孤立肿瘤，无脑膜播散。组织学检查显示为黑色素瘤。采用了由达卡巴嗪、ACNU、长春新碱和干扰素组成的化疗方案。随访影像学研究显示肿瘤显著缩小，4年无复发。本报告表明，无 脑膜播散且有罕见核分裂象的孤立性原发性颅内黑色素瘤化疗可能取得良好效果。
