调节胃肠动力功能。
regulates gastrointestinal motility functions.
作者信息
Kim Iksung, Bae Jinsoo, Kim Byung Joo
机构信息
Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Korea.
出版信息
Integr Med Res. 2017 Dec;6(4):404-408. doi: 10.1016/j.imr.2017.08.005. Epub 2017 Sep 15.
BACKGROUND
Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of (CF), a natural product, on GI motility.
METHODS
We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice . The GMD mice were made by acetic acid or streptozotocin.
RESULTS
Both ITRs and gastric emptying were increased by CF (0.0025-0.25 g/kg) dose dependently. Also, in the GMD mice models, acetic-acid-induced peritoneal irritation, and streptozotocin-induced diabetic mice, the ITRs were decreased compared to normal mice, and these decreases were inhibited by CF.
CONCLUSION
These results suggest that CF is one of the good candidates for the development of a prokinetic agent that may regulate GI-motility functions.
背景
胃肠道（GI）症状在普通人群中很常见。本研究调查了天然产物（CF）对胃肠动力的影响。
方法
我们检测了正常小鼠和胃肠动力功能障碍（GMD）小鼠的肠道转运率（ITRs）或胃排空情况。GMD小鼠通过乙酸或链脲佐菌素制备。
结果
CF（0.0025 - 0.25 g/kg）剂量依赖性地增加了ITRs和胃排空。此外，在GMD小鼠模型、乙酸诱导的腹膜刺激模型和链脲佐菌素诱导的糖尿病小鼠中，与正常小鼠相比ITRs降低，而CF可抑制这些降低。
结论
这些结果表明CF是开发可能调节胃肠动力功能的促动力药物的良好候选物之一。
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