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黄连解毒汤对小鼠胃肠运动功能的影响。

Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice.

作者信息

Kim Hyoyeon, Kim Iksung, Lee Min Cheol, Kim Hyun Jung, Lee Guem San, Kim Hyungwoo, Kim Byung Joo

机构信息

Hyoyeon Kim, Iksung Kim, Min Cheol Lee, Hyun Jung Kim, Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea.

出版信息

World J Gastroenterol. 2017 Apr 21;23(15):2705-2715. doi: 10.3748/wjg.v23.i15.2705.

DOI:10.3748/wjg.v23.i15.2705
PMID:28487607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5403749/
Abstract

AIM

To investigate the effects of Hwangryunhaedok-tang (HHT) on gastrointestinal (GI) motility in mice.

METHODS

The effects of a boiling water extract of HHT (HHTE) on GI motility were investigated by calculating percent intestinal transit rates (ITR%) and gastric emptying (GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). In addition, the effects of the four components of HHT, that is, Gardeniae Fructus (GF), Scutellariae Radix (SR), Coptidis Rhizoma (CR), and Phellodendri Cortex (PC), on GI motility were also investigated.

RESULTS

In normal ICR mice, ITR% and GE values were significantly and dose-dependently increased by the intragastric administration of HHTE (0.1-1 g/kg). The ITR% values of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by HHTE (0.1-1 g/kg). Additionally, GF, CR, and PC dose-dependently increased ITR% and GE values in normal and GMD mice.

CONCLUSION

These results suggest that HHT is a novel candidate for the development of a gastroprokinetic agent for the GI tract.

摘要

目的

研究黄连解毒汤（HHT）对小鼠胃肠动力的影响。

方法

分别使用伊文思蓝和酚红计算正常小鼠及实验性诱导胃肠动力障碍（GMD）小鼠的肠传输率百分比（ITR%）和胃排空（GE）值，以此研究HHT的沸水提取物（HHTE）对胃肠动力的影响。此外，还研究了HHT的四种成分，即栀子（GF）、黄芩（SR）、黄连（CR）和黄柏（PC）对胃肠动力的影响。

结果

在正常ICR小鼠中，胃内给予HHTE（0.1 - 1 g/kg）可显著且剂量依赖性地增加ITR%和GE值。GMD小鼠的ITR%值显著低于正常小鼠，而HHTE（0.1 - 1 g/kg）可显著且剂量依赖性地抑制这些降低。此外，GF、CR和PC在正常和GMD小鼠中剂量依赖性地增加ITR%和GE值。

结论

这些结果表明，HHT是开发胃肠道促动力药物的一种新候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/9e8c1b1964af/WJG-23-2705-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/caa4592b281c/WJG-23-2705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/f667a22bb03a/WJG-23-2705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/3a6c40e3c0e0/WJG-23-2705-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/841e52b574e1/WJG-23-2705-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/940827d1038d/WJG-23-2705-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/9e8c1b1964af/WJG-23-2705-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/caa4592b281c/WJG-23-2705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/f667a22bb03a/WJG-23-2705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/3a6c40e3c0e0/WJG-23-2705-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/841e52b574e1/WJG-23-2705-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/940827d1038d/WJG-23-2705-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f841/5403749/9e8c1b1964af/WJG-23-2705-g006.jpg

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