短异构体的过表达在骨髓增生异常/骨髓增殖性肿瘤的发生发展中起重要作用。
Overexpression of short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms.
作者信息
Sakurai Hiroko, Harada Yuka, Ogata Yosuke, Kagiyama Yuki, Shingai Naoki, Doki Noriko, Ohashi Kazuteru, Kitamura Toshio, Komatsu Norio, Harada Hironori
机构信息
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Clinical Laboratory Medicine, Bunkyo Gakuin University, Tokyo, Japan.
出版信息
Blood Adv. 2017 Jul 31;1(18):1382-1386. doi: 10.1182/bloodadvances.2016002725. eCollection 2017 Aug 8.
Abstract
, but not , is overexpressed in CD34 cells from patients with myelodysplastic/myeloproliferative neoplasms.P95H mutation induces overexpression and a monocytic phenotype in TF-1 cells.
摘要
但在骨髓增生异常综合征/骨髓增殖性肿瘤患者的CD34细胞中，[具体基因或蛋白名称缺失]而非[另一具体基因或蛋白名称缺失]过表达。P95H突变在TF-1细胞中诱导[具体基因或蛋白名称缺失]过表达及单核细胞表型。
相似文献
1
Overexpression of short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms.短异构体的过表达在骨髓增生异常/骨髓增殖性肿瘤的发生发展中起重要作用。
Blood Adv. 2017 Jul 31;1(18):1382-1386. doi: 10.1182/bloodadvances.2016002725. eCollection 2017 Aug 8.
2
RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially in Platelets-Megakaryocytes: Association with Clinical Cardiovascular Events.RUNX1 异构体在血小板 - 巨核细胞中对 RUNX1 和靶基因有不同的调控作用：与临床心血管事件的关联
bioRxiv. 2024 Jun 21:2024.06.18.599563. doi: 10.1101/2024.06.18.599563.
3
RUNX1 isoforms regulate RUNX1 and target genes differentially in platelets-megakaryocytes: association with clinical cardiovascular events.RUNX1 异构体在血小板-巨核细胞中差异调节 RUNX1 和靶基因：与临床心血管事件的关联。
J Thromb Haemost. 2024 Dec;22(12):3581-3598. doi: 10.1016/j.jtha.2024.07.032. Epub 2024 Aug 23.
4
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells.Runx1 异构体在造血发育过程中表现出不同的表达模式，但在成年造血干细胞中具有相似的功能效应。
Exp Hematol. 2010 May;38(5):403-16. doi: 10.1016/j.exphem.2010.02.011. Epub 2010 Mar 3.
5
Gene mutations differently impact the prognosis of the myelodysplastic and myeloproliferative classes of chronic myelomonocytic leukemia.基因突变对骨髓增生异常和骨髓增生性慢性粒单核细胞白血病的预后有不同的影响。
Am J Hematol. 2014 Jun;89(6):604-9. doi: 10.1002/ajh.23702. Epub 2014 Apr 10.
6
Molecular mechanisms that produce secondary MDS/AML by RUNX1/AML1 point mutations.导致 RUNX1/AML1 点突变引起继发性 MDS/AML 的分子机制。
J Cell Biochem. 2011 Feb;112(2):425-32. doi: 10.1002/jcb.22974.
7
[Myeloproliferative/myelodysplastic syndromes].
Rev Prat. 2010 Dec 20;60(10):1413-5.
8
Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.慢性期以及疾病进展过程中骨髓增殖性肿瘤和骨髓增生异常/骨髓增殖性肿瘤的基因组畸变。
Int J Lab Hematol. 2015 Apr;37(2):181-9. doi: 10.1111/ijlh.12257. Epub 2014 May 21.
9
Multicentric study underlining the interest of adding CD5, CD7 and CD56 expression assessment to the flow cytometric Ogata score in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.一项多中心研究强调，在骨髓增生异常综合征和骨髓增生异常/骨髓增殖性肿瘤中，将CD5、CD7和CD56表达评估添加到流式细胞术绪方评分中的意义。
Haematologica. 2015 Apr;100(4):472-8. doi: 10.3324/haematol.2014.112755. Epub 2015 Jan 30.
10
Association of JAK2 mutation status and cytogenetic abnormalities in myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms.骨髓增殖性肿瘤和骨髓增生异常/骨髓增殖性肿瘤中 JAK2 突变状态与细胞遗传学异常的相关性。
Am J Clin Pathol. 2011 May;135(5):709-19. doi: 10.1309/AJCPS6C8EVYCQNRM.
引用本文的文献
1
RUNX1A isoform is overexpressed in acute myeloid leukemia and is associated with FLT3 internal tandem duplications.RUNX1A 异构体在急性髓系白血病中过表达，且与FLT3内部串联重复相关。
Cancer Gene Ther. 2025 Jul 15. doi: 10.1038/s41417-025-00939-z.
2
RUNX1 isoforms regulate RUNX1 and target genes differentially in platelets-megakaryocytes: association with clinical cardiovascular events.RUNX1 异构体在血小板-巨核细胞中差异调节 RUNX1 和靶基因：与临床心血管事件的关联。
J Thromb Haemost. 2024 Dec;22(12):3581-3598. doi: 10.1016/j.jtha.2024.07.032. Epub 2024 Aug 23.
3
RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially in Platelets-Megakaryocytes: Association with Clinical Cardiovascular Events.RUNX1 异构体在血小板 - 巨核细胞中对 RUNX1 和靶基因有不同的调控作用：与临床心血管事件的关联
bioRxiv. 2024 Jun 21:2024.06.18.599563. doi: 10.1101/2024.06.18.599563.
4
RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome.RUNX1 除了在造血方面的作用之外，还有一些新的功能，并且与唐氏综合征有关。
Hum Genomics. 2023 Sep 5;17(1):83. doi: 10.1186/s40246-023-00531-2.
5
Transcriptomic comparison of bone marrow CD34 + cells and peripheral blood neutrophils from ET patients with JAK2 or CALR mutations.骨髓 CD34+细胞和 ET 患者外周血中性粒细胞的转录组比较，这些患者具有 JAK2 或 CALR 突变。
BMC Genom Data. 2023 Aug 7;24(1):40. doi: 10.1186/s12863-023-01142-5.
6
Post-transcriptional regulation of erythropoiesis.红细胞生成的转录后调控。
Blood Sci. 2023 Apr 26;5(3):150-159. doi: 10.1097/BS9.0000000000000159. eCollection 2023 Jul.
7
Novel Molecular Insights into Leukemic Evolution of Myeloproliferative Neoplasms: A Single Cell Perspective.从单细胞角度看骨髓增殖性肿瘤向白血病演变的新分子认识。
Int J Mol Sci. 2022 Dec 3;23(23):15256. doi: 10.3390/ijms232315256.
8
RUNX1 isoform disequilibrium promotes the development of trisomy 21-associated myeloid leukemia.RUNX1 异构体失衡促进 21 三体相关骨髓性白血病的发展。
Blood. 2023 Mar 9;141(10):1105-1118. doi: 10.1182/blood.2022017619.
9
and Genes Expression Level in Adult Acute Lymphoblastic Leukemia-A Case Control Study.以及成人急性淋巴细胞白血病中的基因表达水平——一项病例对照研究
Curr Issues Mol Biol. 2022 Aug 1;44(8):3455-3464. doi: 10.3390/cimb44080238.
10
Molecular Pathogenesis of Myeloproliferative Neoplasms: From Molecular Landscape to Therapeutic Implications.骨髓增殖性肿瘤的分子发病机制：从分子谱到治疗意义。
Int J Mol Sci. 2022 Apr 20;23(9):4573. doi: 10.3390/ijms23094573.
本文引用的文献
1
Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.整合临床特征与基因损伤用于慢性粒单核细胞白血病患者的风险评估
Blood. 2016 Sep 8;128(10):1408-17. doi: 10.1182/blood-2016-05-714030. Epub 2016 Jul 6.
2
The new provisional WHO entity 'RUNX1 mutated AML' shows specific genetics but no prognostic influence of dysplasia.世界卫生组织新的临时实体“RUNX1突变型急性髓系白血病”显示出特定的遗传学特征，但发育异常并无预后影响。
Leukemia. 2016 Oct;30(10):2109-2112. doi: 10.1038/leu.2016.150. Epub 2016 May 23.
3
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.2016 年版世界卫生组织髓系肿瘤和急性白血病分类。
Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.
4
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.SRSF2突变通过对外显子识别的突变特异性影响导致骨髓增生异常。
Cancer Cell. 2015 May 11;27(5):617-30. doi: 10.1016/j.ccell.2015.04.006.
5
Recent advances in myelodysplastic syndromes: Molecular pathogenesis and its implications for targeted therapies.骨髓增生异常综合征的最新进展：分子发病机制及其对靶向治疗的意义。
Cancer Sci. 2015 Apr;106(4):329-36. doi: 10.1111/cas.12614. Epub 2015 Feb 25.
6
LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis.LincRNA-uc002yug.2 参与 RUNX1 的可变剪接，作为食管癌的预测因子和预后指标。
Oncogene. 2015 Sep 3;34(36):4723-34. doi: 10.1038/onc.2014.400. Epub 2014 Dec 8.
7
Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.Runx1 外显子 6 相关的可变剪接异构体在小鼠造血中差异调控。
Blood. 2014 Jun 12;123(24):3760-9. doi: 10.1182/blood-2013-08-521252. Epub 2014 Apr 25.
8
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.RUNX1/AML1 突变与 BMI1 过表达在人类和小鼠骨髓增生异常综合征的发生发展中相互协作。
Blood. 2013 Apr 25;121(17):3434-46. doi: 10.1182/blood-2012-06-434423. Epub 2013 Mar 7.
9
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells.RUNX1a 增强了人类胚胎干细胞和诱导多能干细胞向造血谱系的定向分化。
Blood. 2013 Apr 11;121(15):2882-90. doi: 10.1182/blood-2012-08-451641. Epub 2013 Jan 31.
10
Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.Runx1 缺失或显性抑制通过保守的启动子和远端增强子位点减少 Cebpa 转录，有利于单核细胞生成而不是粒细胞生成。
Blood. 2012 May 10;119(19):4408-18. doi: 10.1182/blood-2011-12-397091. Epub 2012 Mar 26.
Zotero 插件