Paparella P, Francesconi R, Zullo M, Giorgino R, Riccardi P, Ferrazzani S, Mancuso S
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Am J Obstet Gynecol. 1989 Mar;160(3):662-6. doi: 10.1016/s0002-9378(89)80053-5.
2,3-Diphosphoglycerate levels were assayed in 154 pregnant women in third trimester (61 normal, 52 diabetic, 19 with gestational hypertension, 7 with fetal macrosomia, and 15 with idiopathic fetal underdevelopment). A correlation was found between 2,3-diphosphoglycerate levels and birth weight (absolute and relative birth weight or birth weight expressed as percentile), which was negative in normal patients evaluated in the last 7 days before delivery (r = 0.38; p = 0.04) and positive in diabetic patients (evaluated in the third trimester and in the last 7 days before delivery) and in patients with gestational hypertension (evaluated in the third trimester) (r and p values differ according to whether birth weight is expressed as absolute, relative, or a percentile). No correlation was found between 2,3-diphosphoglycerate levels and birth weight in patients with neonatal underdevelopment or macrosomia of unknown origin. On the basis of these results we hypothesize that in some conditions the fetus can influence maternal 2,3-diphosphoglycerate levels and hence its own oxygen supply and growth in utero.
对154名孕晚期孕妇（61名正常孕妇、52名糖尿病孕妇、19名妊娠高血压孕妇、7名胎儿巨大孕妇和15名特发性胎儿发育不全孕妇）的2,3-二磷酸甘油酸水平进行了检测。发现2,3-二磷酸甘油酸水平与出生体重（绝对出生体重和相对出生体重或以百分位数表示的出生体重）之间存在相关性，在分娩前最后7天评估的正常患者中呈负相关（r = 0.38；p = 0.04），在糖尿病患者（在孕晚期和分娩前最后7天评估）和妊娠高血压患者（在孕晚期评估）中呈正相关（r和p值根据出生体重是以绝对值、相对值还是百分位数表示而有所不同）。在不明原因的新生儿发育不全或巨大儿患者中，未发现2,3-二磷酸甘油酸水平与出生体重之间存在相关性。基于这些结果，我们推测在某些情况下，胎儿可以影响母体2,3-二磷酸甘油酸水平，从而影响其自身在子宫内的氧气供应和生长。
