MacLennan A H, Emerson P M, Hunter D J, Darley J H
Br J Obstet Gynaecol. 1976 May;83(5):378-82. doi: 10.1111/j.1471-0528.1976.tb00846.x.
Maternal tissue oxygenation was reflected by the level of red cell, 2,3-diphosphoglycerate (DPG) was measured before, during and after normal pregnancy. Following an initial fall at the beginning of pregnancy there was a significant rise in the mean level of DPG during pregnancy with an abrupt fall in the puerperium. The mean red cell DPG level in the third trimester of pregnancies complicated by pre-eclampsia and diabetes was not statistically different from the normal but the mean value of all pregnancies in which the fetus was stillborn or growth retarded was significantly lower (p less than 0-001). The possible mechanism of the changes in normal and abnormal pregnancy is discussed and it is suggested that the measurement of red cell DPG in the third trimester of pregnancy may prove to be a useful parameter of placental oxygenation.
母体组织氧合作用通过红细胞水平反映，在正常妊娠期间、妊娠前及产后均测量了2,3-二磷酸甘油酸（DPG）。妊娠开始时DPG水平最初下降，之后妊娠期间DPG平均水平显著上升，产褥期则急剧下降。子痫前期和糖尿病合并妊娠的孕晚期红细胞DPG平均水平与正常妊娠无统计学差异，但胎儿死产或生长受限的所有妊娠的平均值显著更低（p小于0.001）。本文讨论了正常和异常妊娠变化的可能机制，并提出在妊娠晚期测量红细胞DPG可能是胎盘氧合作用的一个有用参数。
