Madsen H, Ditzel J
Diabetologia. 1983 Mar;24(3):152-4. doi: 10.1007/BF00250153.
In order to evaluate the possible underlying factors for the increase in red cell 2,3-diphosphoglycerate content observed in late diabetic pregnancy, its relationship with serum unconjugated oestriol, human placental lactogen, haemoglobin and hydrogen ion concentrations was investigated in 42 pregnant diabetic women. A significant correlation was found between red cell 2,3-diphosphoglycerate and serum unconjugated oestriol (r = 0.54, p less than 0.001), whereas no correlation was present between 2,3-diphosphoglycerate and the following variables: arterial pH, haemoglobin concentration and human placental lactogen. The content of 2,3-diphosphoglycerate correlated significantly with haemoglobin-oxygen affinity expressed as P50 at pH 7.4 (r = 0.34, p less than 0.05). The results of this study indicate that serum unconjugated oestriol may participate in the regulation of red cell 2,3-diphosphoglycerate content and thereby of the maternal blood oxygen release to the fetus.
为了评估妊娠晚期糖尿病患者红细胞2,3 - 二磷酸甘油酸含量增加的潜在因素，对42例妊娠糖尿病妇女研究了其与血清非结合雌三醇、人胎盘催乳素、血红蛋白及氢离子浓度的关系。发现红细胞2,3 - 二磷酸甘油酸与血清非结合雌三醇之间存在显著相关性（r = 0.54，p＜0.001），而2,3 - 二磷酸甘油酸与以下变量之间无相关性：动脉pH值、血红蛋白浓度和人胎盘催乳素。2,3 - 二磷酸甘油酸含量与pH 7.4时以P50表示的血红蛋白 - 氧亲和力显著相关（r = 0.34，p＜0.05）。本研究结果表明，血清非结合雌三醇可能参与红细胞2,3 - 二磷酸甘油酸含量的调节，从而参与母体血液向胎儿释放氧气的过程。
