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miR-202 通过靶向表皮生长因子受体抑制人膀胱癌细胞的增殖、迁移和侵袭。

miR-202 Inhibits Cell Proliferation, Migration, and Invasion by Targeting Epidermal Growth Factor Receptor in Human Bladder Cancer.

机构信息

Department of Urology Surgery, General Hospital of Jinan Military Command, Jinan, Shandong, P.R. China.

Department of Pharmacy, General Hospital of Jinan Military Command, Jinan, Shandong, P.R. China.

出版信息

Oncol Res. 2018 Jul 5;26(6):949-957. doi: 10.3727/096504018X15149787144385. Epub 2018 Jan 3.

DOI:10.3727/096504018X15149787144385
PMID:29298735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7844602/
Abstract

Recent studies have demonstrated that miR-202 is associated with several types of cancer; however, the expression and function of miR-202 have not been investigated in bladder cancer. We analyzed the expression of miR-202 in bladder cancer tissues and adjacent noncancerous tissues. The effect of miR-202 on the proliferation, migration, and invasion was evaluated by in vitro assays. The target gene of miR-202 was assessed by luciferase reporter assay. In this study, miR-202 was found to be significantly downregulated in bladder cancer cell lines and tissues and was highly correlated with the T classification, N classification, grade, and recurrence. Ectopic expression of miR-202 suppressed cell viability, colony formation, cell migration, and invasion in vitro and inhibited xenograft tumor growth in vivo. Inversely, downregulation of miR-202 had contradictory effects. The 3'-untranslated region (3'-UTR) of epidermal growth factor receptor (EGFR) was identified as a direct target of miR-202 using luciferase reporter assays, and knockdown of EGFR enhanced miR-202-inhibited cell proliferation, migration, and invasion. In conclusion, miR-202 suppresses bladder cancer carcinogenesis and progression by targeting EGFR, thereby representing a potential target for miRNA-based therapy for bladder cancer in the future.

摘要

最近的研究表明，miR-202 与几种类型的癌症有关；然而，miR-202 在膀胱癌中的表达和功能尚未得到研究。我们分析了膀胱癌组织和相邻非癌组织中 miR-202 的表达。通过体外实验评估了 miR-202 对增殖、迁移和侵袭的影响。通过荧光素酶报告基因检测评估了 miR-202 的靶基因。在这项研究中，miR-202 在膀胱癌细胞系和组织中明显下调，并且与 T 分类、N 分类、分级和复发高度相关。miR-202 的异位表达抑制了细胞活力、集落形成、细胞迁移和侵袭，并抑制了体内异种移植肿瘤的生长。相反，miR-202 的下调则产生相反的效果。表皮生长因子受体 (EGFR) 的 3'-非翻译区 (3'-UTR) 通过荧光素酶报告基因检测被鉴定为 miR-202 的直接靶标，EGFR 的敲低增强了 miR-202 抑制的细胞增殖、迁移和侵袭。总之，miR-202 通过靶向 EGFR 抑制膀胱癌的发生和进展，因此代表了未来膀胱癌基于 miRNA 治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/0331e8a4e536/OR-26-949-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/8b8053f34720/OR-26-949-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/ca22502741fe/OR-26-949-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/d3239582d4d5/OR-26-949-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/6700baa67d61/OR-26-949-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/1c7208d92313/OR-26-949-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/0331e8a4e536/OR-26-949-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/8b8053f34720/OR-26-949-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/ca22502741fe/OR-26-949-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/d3239582d4d5/OR-26-949-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/6700baa67d61/OR-26-949-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/1c7208d92313/OR-26-949-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7663/7844602/0331e8a4e536/OR-26-949-g006.jpg

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本文引用的文献

1
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Cell Physiol Biochem. 2017;44(2):644-656. doi: 10.1159/000485276. Epub 2017 Nov 24.
2
miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer.微小RNA-20b通过直接调控前列腺癌中的磷酸酶及张力蛋白同源物来促进细胞增殖和迁移。
Oncol Lett. 2017 Dec;14(6):6895-6900. doi: 10.3892/ol.2017.7041. Epub 2017 Sep 25.
3
Circulating microRNAs as Biomarkers for Pediatric Astrocytomas.
The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor.
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Int J Mol Sci. 2022 May 24;23(11):5870. doi: 10.3390/ijms23115870.
4
Bladder Cancer-related microRNAs With In Vivo Efficacy in Preclinical Models.在临床前模型中具有体内疗效的膀胱癌相关微小RNA
Cancer Diagn Progn. 2021 Jul 3;1(4):245-263. doi: 10.21873/cdp.10033. eCollection 2021 Sep-Oct.
5
Effects of miR-202-5p silencing PIK3CA gene expression on proliferation, invasion, and epithelial-mesenchymal transition of cervical cancer SiHa cells through inhibiting PI3K/Akt/mTOR signaling pathway activation.沉默 miR-202-5p 对 PIK3CA 基因表达的影响通过抑制 PI3K/Akt/mTOR 信号通路的激活对宫颈癌 SiHa 细胞的增殖、侵袭和上皮间质转化的作用。
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6
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7
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9
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循环微RNA作为小儿星形细胞瘤的生物标志物
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4
An integrated lncRNA, microRNA and mRNA signature to improve prognosis prediction of colorectal cancer.一种用于改善结直肠癌预后预测的lncRNA、miRNA和mRNA综合特征。
Oncotarget. 2017 Aug 7;8(49):85463-85478. doi: 10.18632/oncotarget.20013. eCollection 2017 Oct 17.
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Transl Oncol. 2017 Apr;10(2):168-177. doi: 10.1016/j.tranon.2017.01.001. Epub 2017 Feb 3.
8
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9
Concurrent Autophagy Inhibition Overcomes the Resistance of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Human Bladder Cancer Cells.同时抑制自噬可克服人膀胱癌细胞对表皮生长因子受体酪氨酸激酶抑制剂的耐药性。
Int J Mol Sci. 2017 Feb 4;18(2):321. doi: 10.3390/ijms18020321.
10
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J Appl Toxicol. 2017 Jul;37(7):853-862. doi: 10.1002/jat.3434. Epub 2017 Feb 6.