Maldov D G, Andronova V L, Grigorian S S, Isaeva E I, Deryabin P G, Mishin D V, Balakina A A, Ilyichev A V, Terentyev A A, Galegov G A
ZAO SKY LTD, Moscow, Russia.
Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia.
Dokl Biol Sci. 2017 Nov;477(1):219-222. doi: 10.1134/S0012496617060035. Epub 2018 Jan 4.
Stimforte, an immune response-stimulating preparation, is active with respect to hepatitis C virus (HCV) and herpes simplex virus type I (HSV-1). The effects of Stimforte in animals infected with either HCV or HSV-1 are fundamentally different. In mice with acute herpes virus infection, Stimforte administration leads to a higher activity of natural killer cells and cytotoxic lymphocytes, and the amount of interferon (IFN) λ grows. In mice infected with HCV, Stimforte administration results in a significant increase in IFN-β but not IFN-λ in blood and affected organs. Stimforte has been found to affect directly HCV reproduction that causes the infected cell death, but it does not affect HSV-1 reproduction in the Vero cells (V).
斯迪姆福泰（Stimforte）是一种免疫反应刺激制剂，对丙型肝炎病毒（HCV）和单纯疱疹病毒I型（HSV-1）具有活性。斯迪姆福泰对感染HCV或HSV-1的动物的影响存在根本差异。在患有急性疱疹病毒感染的小鼠中，给予斯迪姆福泰会导致自然杀伤细胞和细胞毒性淋巴细胞的活性更高，并且干扰素（IFN）λ的量会增加。在感染HCV的小鼠中，给予斯迪姆福泰会导致血液和受影响器官中的IFN-β显著增加，但IFN-λ不会增加。已发现斯迪姆福泰直接影响导致受感染细胞死亡的HCV复制，但它不影响Vero细胞（V）中HSV-1的复制。
