ZAO SKY LTD, 129301, Moscow, Russia.
Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation (Ivanovsky Institute of Virology), 123098, Moscow, Russia.
Dokl Biol Sci. 2020 Mar;491(1):50-53. doi: 10.1134/S0012496620020076. Epub 2020 Jun 1.
Stimforte in a wide range of concentrations (15-225 µg/mL) totally inhibits the cytopathic activity of hepatitis C virus (HCV) in the Vero-V cell culture. Interferons (IFN) play the most important role in the suppression of infection when the drug is introduced into the culture before the infection. When Stimforte is introduced after the infection, the mechanism of action seems to be different. The activators of IFN production are mainly (or exclusively) the ligands of receptor complexes TLR-4 and NOD-2 contained in the drug. The action of these substances is probably synergistic, similar to the action of LPS and MDP in Vero-V cells.
Stimforte 在广泛的浓度范围内（15-225μg/mL）完全抑制了 Vero-V 细胞培养中的丙型肝炎病毒（HCV）的细胞病变活性。当药物在感染前引入培养物时，干扰素（IFN）在抑制感染方面发挥最重要的作用。当 Stimforte 在感染后引入时，作用机制似乎不同。IFN 产生的激活剂主要（或完全）是药物中包含的 TLR-4 和 NOD-2 受体复合物配体。这些物质的作用可能是协同的，类似于 LPS 和 MDP 在 Vero-V 细胞中的作用。
