Zhong Meimei, Wang Xiaowen, Li Qifeng, Wu Zhijia, Huang Xiangyuan, Li Xinyue, Lian Yiqing, Peng Yingyi, Li Zhiqiang, Liu Zhifang, Wang Qia, Gong Yajun, Hu Peixia, Liu Xiaoyong, Zhu Shuming, Wu Shaomin, Zeng Fangfang, Qin Yiru, Nong Qiying, Wang Jinhan, Gu Yeqing, Huang Yongshun, Zhang Wangjian, Zhao Na
Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, China.
School of Public Health, Shanxi Medical University, Taiyuan, China.
Front Public Health. 2025 Aug 18;13:1651676. doi: 10.3389/fpubh.2025.1651676. eCollection 2025.
Although radiation workers' exposure levels consistently remained below established safety thresholds, accumulating evidence demonstrates that chronic low-dose ionizing radiation exposure may still pose significant health risks to humans. We aimed to explore the relationship between the years of low-dose radiation work and dyslipidemia.
We collected occupational and physical examination data of 10,338 radiation workers from 1,200 workplaces during 2019-2020 in Guangdong Province, China. After controlling for social demographic and health behavior confounders, we used a mixed-effects model to assess the association of ionizing radiation exposure duration with blood lipid biomarkers as well as the prevalence of dyslipidemia. We further comprehensively evaluated the modifying effects of various demographic characteristics, health behavior factors, and air pollutant concentrations.
We found that participants with prolonged ionizing radiation exposure tended to have 8-40% higher levels of total cholesterol (TC) compared to those with < 10 years of exposure. The estimates were 9-23% for triglycerides (TG) and 5-26% for low-density lipoprotein cholesterol (LDL-C). Similar disparities were observed for the prevalence of overall dyslipidemia, abnormal TC or TG, hypercholesterolemia, hypertriglyceridemia, and high -lipoproteinemia, with odds being 1.51-2.45 times higher in the group with > 30 years of ionizing radiation exposure compared to others. Our estimates further indicated greater effect estimates for prolonged ionizing radiation exposure and the prevalence of lipid abnormalities ( < 0.05) among the females, unmarried ones, and the workers with normal BMI.
These findings suggest a deleterious effect of prolonged ionizing radiation exposure on lipid metabolism, with certain groups of workers being particularly vulnerable.
尽管辐射工作人员的暴露水平一直保持在既定的安全阈值以下，但越来越多的证据表明，长期低剂量电离辐射暴露仍可能对人类健康构成重大风险。我们旨在探讨低剂量辐射工作年限与血脂异常之间的关系。
我们收集了2019 - 2020年期间中国广东省1200个工作场所的10338名辐射工作人员的职业和体检数据。在控制了社会人口统计学和健康行为混杂因素后，我们使用混合效应模型来评估电离辐射暴露持续时间与血脂生物标志物以及血脂异常患病率之间的关联。我们进一步全面评估了各种人口统计学特征、健康行为因素和空气污染物浓度的调节作用。
我们发现，与暴露年限<10年的参与者相比，长期暴露于电离辐射的参与者总胆固醇（TC）水平往往高出8 - 40%。甘油三酯（TG）的估计值为9 - 23%，低密度脂蛋白胆固醇（LDL-C）的估计值为5 - 26%。在总体血脂异常、TC或TG异常、高胆固醇血症、高甘油三酯血症和高脂蛋白血症的患病率方面也观察到类似差异，电离辐射暴露>30年的组与其他组相比，患病几率高出1.51 - 2.45倍。我们的估计进一步表明，长期电离辐射暴露对女性、未婚者和BMI正常的工人的脂质异常患病率影响更大（P<0.05）。
这些发现表明长期电离辐射暴露对脂质代谢有有害影响，某些工人群体尤其脆弱。
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