Åsa von Berens, Rd, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University. Uppsala Science Park, 751 85, Uppsala, Sweden,
J Nutr Health Aging. 2018;22(1):1-7. doi: 10.1007/s12603-016-0849-0.
To examine the potential association between serum 25(OH) vitamin D and the performance on the Short Physical Performance Battery (SPPB) including the sub-components; five repeated chair stands test, 4 meters walk test and balance in older mobility-limited community-dwelling men and women.
A cross sectional study was performed in American and Swedish subjects who were examined for potential participation in a combined exercise and nutrition intervention trial. Logistic regression analysis and linear regression analyses were performed to evaluate the association for 25(OH)D with the overall score on the SBBP, chair stand, gait speed and balance.
Community-dwelling (mean age 77.6 ± 5.3 years) mobility limited American (n=494) and Swedish (n=116) females (59%) and males.
The SPPB (0-12 points) includes chair stand (s), gait speed (m/s) and a balance test. Mobility limitation i.e., SPPB score ≤ 9 was an inclusion criterion. A blood sample was obtained to measure serum 25(OH)vitamin D concentrations.
No clear association of 25(OH)D with SPPB scores was detected either when 25(OH)D was assessed as a continuous variable or when categorized according to serum concentrations of <50, 50-75 or <75 nmol/L. However, when analyzing the relationship between 25(OH)D and seconds to perform the chair stands, a significant quadratic relationship was observed. Thus, at serum levels of 25(OH)D above 74 nmol/L, higher concentrations appeared to be advantageous for the chair stand test, whereas for serum levels below 74 nmol/L this association was not observed.
This cross- sectional study lacked clear association between serum 25(OH)D and physical performance in mobility limited adults. A potentially interesting observation was that at higher serum levels of 25(OH)D a better performance on the chair stand test was indicated.
探讨血清 25（OH）维生素 D 与短期身体表现电池（SPPB）的表现之间的潜在关联，包括五个重复的椅子站立测试、4 米步行测试和平衡，在老年活动受限的社区居住的男性和女性中。
在美国和瑞典进行了一项横断面研究，对这些受试者进行了检查，以评估他们是否有资格参加一项联合运动和营养干预试验。进行逻辑回归分析和线性回归分析，以评估 25（OH）D 与 SBBP 的总体评分、椅子站立、步态速度和平衡的关系。
社区居住（平均年龄 77.6 ± 5.3 岁）活动受限的美国（n=494）和瑞典（n=116）女性（59%）和男性。
SPPB（0-12 分）包括椅子站立（s）、步态速度（m/s）和平衡测试。移动受限，即 SPPB 评分≤9 是纳入标准。采集血样以测量血清 25（OH）维生素 D 浓度。
当以连续变量评估 25（OH）D 或根据血清浓度<50、50-75 或<75 nmol/L 进行分类时，都没有发现 25（OH）D 与 SPPB 评分之间的明显关联。然而，当分析 25（OH）D 与完成椅子站立所需时间之间的关系时，观察到一个显著的二次关系。因此，在血清 25（OH）D 水平高于 74 nmol/L 时，较高的浓度似乎有利于椅子站立测试，而在血清水平低于 74 nmol/L 时，这种关联则不存在。
这项横断面研究缺乏血清 25（OH）D 与活动受限成年人身体表现之间的明确关联。一个有趣的观察结果是，在较高的血清 25（OH）D 水平下，椅子站立测试的表现更好。
