老年人基线尿总多酚和膳食多酚与显著身体机能下降风险之间的关联：InCHIANTI研究的9年随访
Association between Both Total Baseline Urinary and Dietary Polyphenols and Substantial Physical Performance Decline Risk in Older Adults: A 9-year Follow-up of the InCHIANTI Study.
作者信息
Rabassa M, Zamora-Ros R, Andres-Lacueva C, Urpi-Sarda M, Bandinelli S, Ferrucci L, Cherubini A
机构信息
C. Andres-Lacueva, Biomarkers and Nutrimetabolomic Laboratory, Nutrition and Food Science Department, Campus Torribera, Pharmacy and Food Sciences Faculty, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain. E-mail:
出版信息
J Nutr Health Aging. 2016;20(5):478-85. doi: 10.1007/s12603-015-0600-2.
IMPORTANCE
The decline in physical performance that occurs in many older subjects is a strong predictor of falls, hospitalization, institutionalization and mortality. Polyphenols are bioactive compounds that may play a preventive role against physical performance decline due to their antioxidant and anti-inflammatory properties.
OBJECTIVE
To investigate the association between total urinary polyphenols (TUP) and total dietary polyphenols (TDP) and substantial physical performance decline over a nine-year period among older subjects.
METHODS
This longitudinal study included 368 participants aged 65 years or older from the InCHIANTI (Invecchiare in Chianti) study, an Italian population-based cohort. TUP and TDP concentrations were assessed at baseline using the Folin-Ciocalteau (F-C) assay and a validated food frequency questionnaire, respectively. Physical performance was objectively measured at baseline and at nine-year follow-up using the Short Physical Performance Battery (SPPB). A substantial decline in physical performance was considered as a decrease of three or more points in the SPPB score.
RESULTS
At the nine-year follow-up assessment, 71 participants had suffered a substantial decline in physical performance. In the fully adjusted logistic regression model, participants in the highest TUP tertile had a lower risk of substantial decline in physical performance than those in the lowest tertile (OR, 0.40; 95% CI, 0.17-0.93; P trend=0.033). However, no significant association between TDP intake and physical performance decline was observed.
CONCLUSION
This study shows that high TUP concentrations, a biomarker of polyphenol-rich exposure, were associated with lower risk of substantial decline in physical performance in community-dwelling older subjects over a nine-year period. These results suggest that a polyphenol-rich diet may play a role in protecting against physical performance decline in older people.
重要性
许多老年受试者出现的身体机能下降是跌倒、住院、入住养老院和死亡的有力预测指标。多酚是具有生物活性的化合物，因其抗氧化和抗炎特性，可能对预防身体机能下降起到作用。
目的
研究老年受试者在九年期间总尿多酚（TUP）和总膳食多酚（TDP）与身体机能大幅下降之间的关联。
方法
这项纵向研究纳入了来自意大利基于人群的队列研究“基安蒂地区老龄化研究（InCHIANTI）”的368名65岁及以上的参与者。分别使用福林 - 西奥尔特（Folin - Ciocalteau，F - C）法和经过验证的食物频率问卷在基线时评估TUP和TDP浓度。使用简短身体机能测试量表（SPPB）在基线和九年随访时客观测量身体机能。身体机能的大幅下降被定义为SPPB评分下降三分或更多。
结果
在九年随访评估中，71名参与者身体机能出现了大幅下降。在完全调整的逻辑回归模型中，TUP三分位数最高的参与者身体机能大幅下降的风险低于三分位数最低的参与者（比值比[OR]，0.40；95%置信区间[CI]，0.17 - 0.93；P趋势 = 0.033）。然而，未观察到TDP摄入量与身体机能下降之间存在显著关联。
结论
本研究表明，高TUP浓度作为富含多酚暴露的生物标志物，与社区居住的老年受试者在九年期间身体机能大幅下降的较低风险相关。这些结果表明，富含多酚的饮食可能在预防老年人身体机能下降方面发挥作用。
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