Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Genome Med. 2018 Jan 4;10(1):1. doi: 10.1186/s13073-017-0512-3.
Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.
我们对精神疾病的神经生物学的理解仍然有限，基于生物标志物的临床管理尚待开发。诱导多能干细胞 (iPSC) 技术极大地提高了我们生成患者来源神经元以模拟精神疾病的能力。在这里，我们强调了 iPSC 疾病建模的优点和注意事项，并概述了应对当前挑战的策略。
