CD1A 和 CD1E 基因多态性与孟加拉国人群吉兰-巴雷综合征易感性无关。
CD1A and CD1E gene polymorphisms are not associated with susceptibility to Guillain-Barré syndrome in the Bangladeshi population.
机构信息
Laboratory Sciences and Services Division, International Centre for Diarrheal Disease Research (icddr,b), Dhaka, Bangladesh.
Laboratory Sciences and Services Division, International Centre for Diarrheal Disease Research (icddr,b), Dhaka, Bangladesh; Department of Genetic Engineering and Biotechnology, University of Dhaka, Bangladesh.
出版信息
J Neuroimmunol. 2018 Jan 15;314:8-12. doi: 10.1016/j.jneuroim.2017.11.013. Epub 2017 Nov 22.
The post-infectious autoimmune polyradiculoneuropathy Guillain-Barré syndrome (GBS) is triggered by molecular mimicry between microbial glycolipid antigens and human peripheral nerve gangliosides. Single nucleotide polymorphisms in exon 2 of CD1A (*01/*02) and CD1E (01/02) were assessed using PCR-RFLP; no significant differences in genotype or allele frequency were observed between 200 patients with GBS and 200 healthy controls. CD1 gene polymorphisms cannot be recognized as a susceptibility or disease-causative factor for GBS in the Bangladeshi population. However, further studies are necessary to investigate the CD1A01/CD1E01 haplotype distribution and its potential causative role in the axonal form of GBS.
感染后自身免疫性多神经根神经病吉兰-巴雷综合征（GBS）是由微生物糖脂抗原与人体周围神经神经节苷脂之间的分子模拟触发的。使用 PCR-RFLP 评估 CD1A（*01/*02）和 CD1E（01/02）外显子 2 的单核苷酸多态性；在 200 例 GBS 患者和 200 例健康对照者之间，基因型或等位基因频率无显著差异。CD1 基因多态性不能被认为是孟加拉人群中 GBS 的易感性或致病因素。然而，需要进一步研究 CD1A01/CD1E01 单倍型分布及其在 GBS 轴索性形式中的潜在致病作用。
Zotero 插件