秘鲁暴发格林-巴利综合征：与 IL-17、ICAM1 和 CD1 多态性的关联
Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1.
机构信息
INBIOMEDIC Research and Technological Center, Lima, Peru.
ALBIOTEC, Lima, Peru.
出版信息
Mol Genet Genomic Med. 2019 Oct;7(10):e00960. doi: 10.1002/mgg3.960. Epub 2019 Aug 28.
BACKGROUND
Guillain-Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17, and/or ICAM1 had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018.
METHODS
A total of nine nonrelated cases and 11 controls were sequenced for the polymorphic regions of CD1A, CD1E, IL-17, and ICAM1.
RESULTS
We found a significant protective association between heterozygous GA genotype in ICAM1 (241Gly/Arg) and GBS (p < .047). IL-17 was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in CD1A and CD1E between the group with GBS patients and healthy controls.
CONCLUSION
ICAM1 polymorphisms might be considered as potential genetic markers of GBS susceptibility. Further studies with larger sample size will be required to validate these findings.
背景
吉兰-巴雷综合征（GBS）被认为是一种复杂的疾病，具有显著的环境影响和遗传易感性。在高加索人群中，CD1E、CD1A、IL-17 和/或 ICAM1 中的遗传多态性被认为是 GBS 的易感遗传变异体。本研究旨在探讨这些基因中的选定多态性与秘鲁北部梅斯蒂索人群中 2018 年 5 月最近一次 GBS 暴发期间确诊的 GBS 病例易感性之间的关系。
方法
对 9 名无亲缘关系的病例和 11 名对照者进行了 CD1A、CD1E、IL-17 和 ICAM1 多态性区域的测序。
结果
我们发现 ICAM1（241Gly/Arg）杂合 GA 基因型与 GBS 之间存在显著的保护相关性（p<.047）。IL-17 在对照组和患者中均为单态性。GBS 患者组和健康对照组之间 CD1A 和 CD1E 中 SNP 的频率无显著差异。
结论
ICAM1 多态性可能被认为是 GBS 易感性的潜在遗传标志物。需要更大样本量的进一步研究来验证这些发现。
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