依赖输血的地中海贫血患者感染耐药模式的当前趋势

Current Trends of Drug Resistance Patterns of Infection in Blood Transfusion-dependent Thalassemia Patients.

作者信息

Almani Suhail Ahmed, Naseer Ali, Maheshwari Sanjay Kumar, Maroof Pir, Naseer Raza, Khoharo Haji Khan

机构信息

Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.

Department of Medicine, Abbasi Shaheed Hospital, Karachi, Pakistan.

出版信息

J Glob Infect Dis. 2017 Oct-Dec;9(4):135-138. doi: 10.4103/jgid.jgid_151_16.

DOI:10.4103/jgid.jgid_151_16

PMID:29302147

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5750436/

Abstract

OBJECTIVE

The present study aimed to evaluate the current trends of drug resistance patterns of infection in blood transfusion-dependent thalassemia patients.

STUDY DESIGN

This study was a cross sectional study, conducted at the Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, Sindh, Pakistan from October 2014 to January 2016.

SUBJECTS AND METHODS

Of 921 blood samples, strains were isolated from 100 blood samples. Blood samples were processed for the isolation, identification, and drugs sensitivity as per the Clinical and Laboratory Standards Institute. strains were identified by microbiological methods and Gram's staining. API 20 E kit (Biomeriuex, USA) was also used for identification. Data were analyzed on Statisti × 8.1 (USA).

RESULTS

Mean ± standard deviation age was 11.5 ± 2.8 years. Nearly 70% were male and 30% were female ( = 0.0001). Of 921 blood transfusion-dependent thalassemia patients, 100 (10.8%) patients showed growth of . Drug resistance was observed against the ceftazidime, cefixime, cefepime, imipenem, meropenem, amikacin, minocycline, tigecycline, and tazocin except for the colistin.

CONCLUSION

The present study reports drug-resistant in blood transfusion-dependent thalassemia patients. National multicenter studies are recommended to estimate the size of the problem.

摘要

目的

本研究旨在评估依赖输血的地中海贫血患者感染耐药模式的当前趋势。

研究设计

本研究为横断面研究，于2014年10月至2016年1月在巴基斯坦信德省詹姆肖罗/海得拉巴德的利亚卡特医学与健康科学大学开展。

研究对象与方法

在921份血样中，从100份血样中分离出菌株。按照临床和实验室标准协会的标准对血样进行分离、鉴定及药敏试验。通过微生物学方法和革兰氏染色鉴定菌株。还使用API 20 E试剂盒（美国生物梅里埃公司）进行鉴定。数据采用Statisti × 8.1（美国）进行分析。

结果

平均年龄±标准差为11.5±2.8岁。近70%为男性，30%为女性（P = 0.0001）。在921例依赖输血的地中海贫血患者中，100例（10.8%）患者的[具体细菌名称未给出]呈生长状态。除黏菌素外，观察到对头孢他啶、头孢克肟、头孢吡肟、亚胺培南、美罗培南、阿米卡星、米诺环素、替加环素和他唑仙耐药。