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丁丙诺啡治疗阿片类物质依赖：最新进展

Treatment of opioid dependence with buprenorphine: current update.

作者信息

Soyka Michael

机构信息

Medical Park Chiemseeblick, Bernau, Germany; Psychiatric Hospital, University of Munich, Munich, Germany.

出版信息

Dialogues Clin Neurosci. 2017 Sep;19(3):299-308. doi: 10.31887/DCNS.2017.19.3/msoyka.

DOI:10.31887/DCNS.2017.19.3/msoyka
PMID:29302227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5741113/
Abstract

Opioid maintenance treatment is the first-line approach in opioid dependence. Both the full opioid agonist methadone (MET) and the partial agonist buprenorphine (BUP) are licensed for the treatment of opioid dependence. BUP differs significantly from MET in its pharmacology, side effects, and safety issues. For example, the risk of respiratory depression is lower than with MET. The risk of diversion and injection of BUP have been reduced by also making it available as a tablet containing the opioid antagonist naloxone. This review summarizes the clinical effects of BUP and examines possible factors that can support decisions regarding the use of BUP or MET in opioid-dependent people.

摘要

阿片类药物维持治疗是阿片类药物依赖的一线治疗方法。完全阿片类激动剂美沙酮（MET）和部分激动剂丁丙诺啡（BUP）均被批准用于治疗阿片类药物依赖。BUP在药理学、副作用和安全性问题上与MET有显著差异。例如，其呼吸抑制风险低于MET。通过将其制成含有阿片类拮抗剂纳洛酮的片剂，也降低了BUP被转移和注射的风险。本综述总结了BUP的临床效果，并探讨了可能有助于决定在阿片类药物依赖者中使用BUP或MET的因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e632/5741113/a600b9632ab5/DialoguesClinNeurosci-19-299-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e632/5741113/18b902ec0b06/DialoguesClinNeurosci-19-299-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e632/5741113/9565620246be/DialoguesClinNeurosci-19-299-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e632/5741113/a600b9632ab5/DialoguesClinNeurosci-19-299-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e632/5741113/18b902ec0b06/DialoguesClinNeurosci-19-299-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e632/5741113/9565620246be/DialoguesClinNeurosci-19-299-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e632/5741113/a600b9632ab5/DialoguesClinNeurosci-19-299-g003.jpg

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