Varshney Prateek, Bhargav Hemant, Vidyasagar Pilli Devi, Venugopal Sumana, Arsappa Rashmi, Narasimha Venkata Lakshmi, Sharma Priyamvada, Rao Vijayashree, Murthy Pratima
Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Main Road, Bengaluru 560029, India.
Department of Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Main Road, Bengaluru 560029, India.
Case Rep Psychiatry. 2021 Jul 23;2021:5541995. doi: 10.1155/2021/5541995. eCollection 2021.
Opioid dependence syndrome (ODS) is a chronic relapsing remitting condition associated with significant impairment and mortality risk. Opioid substitution therapy is used worldwide, but long-term retention rates are low and there is risk of misuse and diversion. Yoga practice can improve quality of life, reduce chronic pain, and enhance endogenous opioids (beta-endorphins). We describe a case of ODS where yoga was added to the conventional management and who was followed up for 9 months. Assessments were done for clinical symptoms, urine drug screening, plasma beta-endorphins, and Buprenorphine dosage. We observed an improvement in his clinical symptoms and reduction in the requirements for Buprenorphine. A slight increase in basal plasma beta-endorphin levels was also observed at the 9-month follow-up (from 2.02 pmol/L at baseline to 6.51 pmol/L).
阿片类物质依赖综合征（ODS）是一种慢性复发性缓解性疾病，伴有严重功能障碍和死亡风险。阿片类物质替代疗法在全球范围内使用，但长期留存率较低，且存在滥用和转移的风险。瑜伽练习可以改善生活质量、减轻慢性疼痛并增强内源性阿片类物质（β-内啡肽）。我们描述了一例ODS患者，在其常规治疗中加入了瑜伽，并对其进行了9个月的随访。对临床症状、尿液药物筛查、血浆β-内啡肽和丁丙诺啡剂量进行了评估。我们观察到其临床症状有所改善，丁丙诺啡的需求量减少。在9个月的随访中还观察到基础血浆β-内啡肽水平略有升高（从基线时的2.02 pmol/L升至6.51 pmol/L）。
