阿片肽对心血管衰老的影响。
Effects of Apelin on Cardiovascular Aging.
作者信息
Zhou Ying, Wang Yong, Qiao Shubin, Yin Liang
机构信息
Department of Cardiology, China-Japan Friendship Hospital, Beijing, China.
Department of Cardiology, Cardiovascular Institute of Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
出版信息
Front Physiol. 2017 Dec 12;8:1035. doi: 10.3389/fphys.2017.01035. eCollection 2017.
Abstract
Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin-APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in the elderly, such as atherosclerosis, coronary atherosclerotic heart disease, hypertension, calcific aortic valve disease, heart failure and atrial fibrillation. In this review, we discuss the apelin-APJ signal transduction pathway related to age-associated cardiovascular diseases.
摘要
Apelin是孤儿G蛋白偶联受体APJ的内源性配体。Apelin-APJ信号转导通路在心血管系统中广泛表达，是心血管稳态的重要因素。长期以来，该信号转导通路一直与老年人中高发病率的疾病相关，如动脉粥样硬化、冠状动脉粥样硬化性心脏病、高血压、钙化性主动脉瓣疾病、心力衰竭和心房颤动。在本综述中，我们讨论了与年龄相关的心血管疾病相关的Apelin-APJ信号转导通路。
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