Funk Stephanie, Kermer Josephine, Doganguezel Serkan, Schwenke Carsten, von Knobelsdorff-Brenkenhoff Florian, Schulz-Menger Jeanette
a Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité - Universitätsmedizin Berlin, Department of Internal Medicine and Cardiology and the Max-Delbrueck Center for Molecular Medicine, and HELIOS Klinikum Berlin Buch, Department of Cardiology and Nephrology , Berlin , Germany.
b DZHK (German Center for Cardiovascular Research), partner Site Berlin , Germany.
Scand Cardiovasc J. 2018 Apr;52(2):85-92. doi: 10.1080/14017431.2017.1423107. Epub 2018 Jan 5.
In recent years the impact of the left atrium (LA) has become more evident in different cardiovascular pathologies. We aim to provide LA parameters in healthy volunteers for cardiovascular magnetic resonance (CMR) using a fast approach.
We analyzed 203 healthy volunteers (mean age 44.6 years (y), range 19y-76y) at 1.5 and 3.0 Tesla (T) using steady-state free precession (SSFP) cine in routine long axis view. Left atrial enddiastolic volume (LA-EDV), endsystolic volume (LA-ESV), stroke volume (LA-SV) and ejection fraction (LA-EF) were quantified and indexed to body-surface-area (BSA). Dependency on age and sex was analyzed.
21 subjects had to be excluded. In the remaining, there was no significant difference between 1.5 T and 3.0 T. Absolut LA-EDV and LA-ESV were larger in men than in women (LA-EDV: male 70 ± 19 ml vs. female 61 ± 16 ml (p = .001); LA-ESV: male 24 ± 9 ml vs. female 21 ± 8 ml (p = .01)). These differences disappeared after indexing to BSA (LA-EDV/BSA: male 34 ± 10 ml/m vs. female 33 ± 9 ml/m (p = .65) and LA-ESV/BSA: male 12 ± 4 ml/m vs. female 11 ± 4 ml/m (p = .71)). LA-EDV/BSA decreased with older age.
Reference values for LA size and function based on a fast approach are provided. LA size decreases with older age. Normalization to body size overcomes sex-dependency. Reports should be related to body size.
近年来，左心房（LA）在不同心血管疾病中的影响愈发明显。我们旨在采用一种快速方法，为健康志愿者提供心血管磁共振（CMR）检查中的左心房参数。
我们使用稳态自由进动（SSFP）电影序列，在常规长轴视图下，对203名健康志愿者（平均年龄44.6岁，范围19岁至76岁）进行了1.5特斯拉（T）和3.0特斯拉的检查。对左心房舒张末期容积（LA-EDV）、收缩末期容积（LA-ESV）、每搏输出量（LA-SV）和射血分数（LA-EF）进行了量化，并根据体表面积（BSA）进行了指数化处理。分析了其与年龄和性别的相关性。
21名受试者被排除。在其余受试者中，1.5T和3.0T之间无显著差异。男性的绝对LA-EDV和LA-ESV大于女性（LA-EDV：男性70±19ml vs.女性61±16ml（p = 0.001）；LA-ESV：男性24±9ml vs.女性21±8ml（p = 0.01））。在根据BSA进行指数化处理后，这些差异消失（LA-EDV/BSA：男性34±10ml/m vs.女性33±9ml/m（p = 0.65），LA-ESV/BSA：男性12±4ml/m vs.女性11±4ml/m（p = 0.71））。LA-EDV/BSA随年龄增长而降低。
提供了基于快速方法的左心房大小和功能的参考值。左心房大小随年龄增长而减小。根据身体大小进行标准化可克服性别依赖性。报告应与身体大小相关。
