Cardiac Imaging Unit, ERESA, Valencia, Spain.
J Cardiovasc Magn Reson. 2010 Nov 11;12(1):65. doi: 10.1186/1532-429X-12-65.
Left atrial (LA) size is related to cardiovascular morbidity and mortality. Cardiovascular magnetic resonance (CMR) provides high quality images of the left atrium with high temporal resolution steady state free precession (SSFP) cine sequences. We used SSFP cines to define normal ranges for LA volumes and dimensions relative to gender, age and body surface area (BSA), and examine the relative value of 2D atrial imaging techniques in patients.For definition of normal ranges of LA volume we studied 120 healthy subjects after careful exclusion of cardiovascular abnormality (60 men, 60 women; 20 subjects per age decile from 20 to 80 years). Data were generated from 3-dimensional modeling, including tracking of the atrioventricular ring motion and time-volume curves analysis. For definition of the best 2D images-derived predictors of LA enlargement, we studied 120 patients (60 men, 60 women; age range 20 to 80 years) with a clinical indication for CMR.
In the healthy subjects, age was associated with LA 4-chamber transverse and 3-chamber anteroposterior diameters, but not with LA volume. Gender was an independent predictor of most absolute LA dimensions and volume, but following normalization to BSA, some associations became non-significant. CMR normal ranges were modeled and are tabled for clinical use with normalization, where appropriate, for BSA and gender and display of parameter variation with age. The best 2D predictors of LA volume were the 2-chamber area and 3-chamber area (both r = 0.90, p < 0.001).
These CMR data show that LA dimensions and volume in healthy, individuals vary significantly by BSA, with lesser effects of age and gender.
左心房（LA）的大小与心血管发病率和死亡率有关。心血管磁共振（CMR）提供了具有高时间分辨率稳态自由进动（SSFP）电影序列的高质量左心房图像。我们使用 SSFP 电影来定义与性别、年龄和体表面积（BSA）相关的 LA 容积和尺寸的正常范围，并检查 2D 心房成像技术在患者中的相对价值。为了定义 LA 容积的正常范围，我们在仔细排除心血管异常（60 名男性，60 名女性；每个年龄十分位数有 20 名受试者，年龄范围为 20 至 80 岁）后研究了 120 名健康受试者。数据来自三维建模，包括房室环运动的跟踪和时容积曲线分析。为了定义最佳的 2D 图像衍生的 LA 扩大预测因子，我们研究了 120 名有 CMR 临床指征的患者（60 名男性，60 名女性；年龄范围为 20 至 80 岁）。
在健康受试者中，年龄与 LA 四腔横径和三腔前后径相关，但与 LA 容积无关。性别是大多数绝对 LA 尺寸和容积的独立预测因子，但在归一化到 BSA 后，一些关联变得不显著。CMR 正常范围进行了建模，并以表格形式展示，以便临床使用，包括适当的 BSA 和性别归一化以及参数随年龄的变化显示。LA 容积的最佳 2D 预测因子是两腔面积和三腔面积（两者 r = 0.90，p < 0.001）。
这些 CMR 数据表明，在健康个体中，LA 的尺寸和容积因 BSA 而有显著差异，而年龄和性别影响较小。
