Institute for Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr-University of Bochum, Georgstr. 11, 32545, Bad Oeynhausen, Germany.
Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr-University of Bochum, Bad Oeynhausen, Germany.
Sci Rep. 2022 Jul 18;12(1):12233. doi: 10.1038/s41598-022-16143-0.
Left-atrial (LA) strain is the result of complex hemodynamics, which may be better characterized using a multiparametric approach. Cardiovascular magnetic resonance (CMR) feature tracking was used to perform a comprehensive LA strain assessment of 183 enrolled healthy volunteers (11-70 years, 97 females, median 32.9 ± 28.3 years). Novel strain dependencies were assessed using multi-parametric regression (MPR) analyses. LA volumetric data, left ventricular strain, transmitral and pulmonary venous blood flow parameters were utilized to create clusters for MPR of all subjects and a heart rate controlled subgroup (pulse: 60-75/min, N = 106). The LA reservoir(r) and conduit(c) strains of the total cohort were significantly elevated (p ≤ 0.001) in women (r: 49.7 ± 12.9%, c: 32.0 ± 11.0%) compared to men (r: 42.9 ± 11.4%, c: 26.1 IQ 10.5%). In contrast, there were no gender-specific differences (p > 0.05) for subgroup LA reservoir, conduit and booster(b) strains (all, r: 47.3 ± 12.7%; c: 29.0 IQ 15.5%; b: 17.6 ± 5.4%) and strain rates (all, 2.1 IQ 1.0 s; - 2.9 IQ 1.5 s; - 2.3 IQ 1.0 s). MPR found large effect sizes (|R|≥ 0.26) for correlations between strain and various cardiac functional parameters. Largest effect size was found for the association between LA conduit strain and LA indexed booster volume, LA total ejection fraction, left ventricular global radial strain and E-wave (|R|= 0.437). In addition to providing normal values for sex-dependent LA strain and strain rate, no gender differences were found with modified heart rate. MPR analyses of LA strain/strain rate and various cardiac functional parameters revealed that heart rate control improved goodness-of-fit for the overall model.
左心房（LA）应变是复杂血液动力学的结果，使用多参数方法可以更好地描述。心血管磁共振（CMR）特征跟踪用于对 183 名健康志愿者（11-70 岁，97 名女性，中位数 32.9±28.3 岁）进行全面的 LA 应变评估。使用多参数回归（MPR）分析评估新型应变依赖性。利用 LA 容积数据、左心室应变、二尖瓣和肺静脉血流参数，为所有受试者和心率控制亚组（脉搏：60-75/min，N=106）创建 MPR 聚类。总队列的 LA 储备（r）和输送（c）应变在女性（r：49.7±12.9%，c：32.0±11.0%）中显著升高（p≤0.001），而在男性（r：42.9±11.4%，c：26.1 IQ 10.5%）中则无显著差异。相比之下，在亚组 LA 储备、输送和增强（b）应变（均为 r：47.3±12.7%；c：29.0 IQ 15.5%；b：17.6±5.4%）和应变率（均为 2.1 IQ 1.0 s；-2.9 IQ 1.5 s；-2.3 IQ 1.0 s）方面，性别间无差异（p>0.05）。MPR 发现应变与各种心功能参数之间的相关性具有较大的效应量（|R|≥0.26）。LA 输送应变与 LA 索引增强体积、LA 总射血分数、左心室整体径向应变和 E 波之间的相关性具有最大的效应量（|R|=0.437）。除了提供性别依赖的 LA 应变和应变率的正常值外，在修改心率后未发现性别差异。LA 应变/应变率与各种心功能参数的 MPR 分析表明，心率控制改善了整体模型的拟合优度。
