Lysell Henrik, Dahlin Marie, Viktorin Alexander, Ljungberg Elsa, D'Onofrio Brian M, Dickman Paul, Runeson Bo
Department of Clinical Neuroscience, Karolinska Institutet, Centre for psychiatry research, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
PLoS One. 2018 Jan 5;13(1):e0190133. doi: 10.1371/journal.pone.0190133. eCollection 2018.
Recent research suggests that having a newborn child is associated with substantially reduced risk for maternal suicide. We studied postpartum suicides in a national cohort of mothers and the role of mental disorder, self-harm and delivery related factors.
We used a nested case-control design with data from Swedish registries. The cohort consisted of all women given birth in Sweden 1974-2009. Mothers who died by suicide during follow-up were considered cases (n = 1,786) and risk of suicide was estimated with proximity to delivery as the explanatory variable. In a second step, association between suicide during the first year following delivery (n = 145) and mental disorder, self-harm and delivery related variables risk factors were analyzed.
The first postpartum year was associated with a lower risk of suicide, compared to later (RR 0.80, 95%CI 0.66-0.96), which was unaltered after adjustment for socio-economic status and history of self-harm (aRR 0.82, 95%CI 0.68-0.99). Compared to living mothers, suicide victims of the postpartum year more often had affective disorders (aRR 133.94, 95%CI 45.93-390.61), psychotic disorders (aRR 83.69, 95%CI 36.99-189.31) and history of self-harm (aRR 47.56, 95%CI 18.24-124.02). The aRR of stillbirth was 2.66 (95%CI 0.63-11.30).
We found only a weak negative association between childbirth during the preceding year and suicide, when using mothers as controls. A severe mental disorder after delivery and a history of self-harm was strongly associated with increased risk of suicide in the postpartum year and may inform the clinical assessment postpartum.
近期研究表明,生育新生儿与大幅降低产妇自杀风险相关。我们在一个全国性的母亲队列中研究了产后自杀情况以及精神障碍、自我伤害和分娩相关因素的作用。
我们采用巢式病例对照设计,使用瑞典登记处的数据。该队列由1974年至2009年在瑞典分娩的所有女性组成。随访期间死于自杀的母亲被视为病例(n = 1786),以分娩时间作为解释变量估计自杀风险。第二步,分析分娩后第一年自杀(n = 145)与精神障碍、自我伤害及分娩相关变量危险因素之间的关联。
与之后的时间相比,产后第一年自杀风险较低(风险比0.80,95%置信区间0.66 - 0.96),在调整社会经济状况和自我伤害史后这一结果未改变(调整后风险比0.82,95%置信区间0.68 - 0.99)。与存活母亲相比,产后一年的自杀受害者更常患有情感障碍(调整后风险比133.94,95%置信区间45.93 - 390.61)、精神障碍(调整后风险比83.69,95%置信区间36.99 - 189.31)和有自我伤害史(调整后风险比47.56,95%置信区间18.24 - 124.02)。死产的调整后风险比为2.66(95%置信区间0.63 - 11.30)。
以母亲作为对照时,我们发现前一年分娩与自杀之间仅存在微弱的负相关。分娩后严重的精神障碍和自我伤害史与产后一年自杀风险增加密切相关,这可能为产后临床评估提供参考。