Gilad G M, Shiller I
Center for Neuroscience and Behavioral Research, Weizmann Institute of Science, Rehovot, Israel.
Behav Brain Res. 1989 Feb 1;32(1):89-93. doi: 10.1016/s0166-4328(89)80076-2.
The study characterizes differences between inbred Wistar-Kyoto (WKYs) and Brown-Norway (BNs) rats in open-field behavior, and in discriminative learning and acquisition of an avoidance learning task. Hyper-reactivity of WKYs to novelty was demonstrated in an open-field test. Discriminative learning and retention thereof was slower in WKYs, but as efficient as in BNs. Acquisition of avoidance learning was also slower in WKYs, but their maximal avoidance score was much higher (approximately 85%) than in BNs. Also, recall of avoidance learning was slower for WKYs. We conclude: (1) hyper-reactivity of WKYs to novelty is expressed by their exceptional immobility and excess defecation in the open-field and is paralleled by their known hyper-reactivity to stressful stimuli, and (2) no strain differences exist in the ability to learn a discriminative task, but both acquisition and recall of an avoidance task are slower in WKYs. This may imply that the degree of reactivity to stressful environmental stimuli may play an important role in the acquisition of learning.
该研究描述了近交系Wistar-Kyoto大鼠（WKYs）和Brown-Norway大鼠（BNs）在旷场行为、辨别学习以及回避学习任务习得方面的差异。在旷场试验中证实了WKYs对新异刺激的高反应性。WKYs的辨别学习及其保持较慢，但与BNs一样有效。WKYs的回避学习习得也较慢，但其最大回避分数比BNs高得多（约85%）。此外，WKYs对回避学习的回忆也较慢。我们得出结论：（1）WKYs对新异刺激的高反应性表现为它们在旷场中异常静止和过度排便，这与其已知的对应激刺激的高反应性相似；（2）在学习辨别任务的能力上不存在品系差异，但WKYs的回避任务习得和回忆都较慢。这可能意味着对应激性环境刺激的反应程度可能在学习习得中起重要作用。
