Departments of Medicine and Physiology, Division of Endocrinology and Metabolism, Banting and Best Diabetes Centre, University of Toronto, Toronto, ON, Canada.
Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.
Trends Endocrinol Metab. 2018 Mar;29(3):151-163. doi: 10.1016/j.tem.2017.12.001. Epub 2018 Jan 3.
Dietary lipid absorption and lipoprotein secretion by the gut are important in maintaining whole-body energy homeostasis and have significant implications for health and disease. The processing of dietary lipids, including storage within and subsequent mobilization and transport from enterocyte cytoplasmic lipid droplets or other intestinal lipid storage pools (including the secretary pathway, lamina propria and lymphatics) and secretion of chylomicrons, involves coordinated steps that are subject to various controls. This review summarizes recent advances in our understanding of the mechanisms that underlie lipid storage and mobilization by small intestinal enterocytes and the intestinal lymphatic vasculature. Therapeutic targeting of lipid processing by the gut may provide opportunities for the treatment and prevention of dyslipidemia, and for improving health status.
饮食中的脂质吸收和脂蛋白分泌对维持全身能量平衡至关重要，对健康和疾病有着重要的影响。包括储存、随后从肠细胞细胞质脂滴或其他肠道脂质储存池（包括分泌途径、固有层和淋巴管）动员和转运，以及乳糜微粒分泌在内的膳食脂质的加工涉及到协调的步骤，这些步骤受到各种控制。本综述总结了我们对小肠肠细胞和肠道淋巴血管系统中脂质储存和动员的基础机制的理解的最新进展。通过肠道对脂质处理进行治疗性靶向可能为治疗和预防血脂异常以及改善健康状况提供机会。
