Sandström T, Stjernberg N, Andersson M C, Kolmodin-Hedman B, Lundgren R, Angström T
Department of Lung Medicine, University Hospital, Umea, Sweden.
Br J Ind Med. 1989 Mar;46(3):200-3. doi: 10.1136/oem.46.3.200.
Bronchoalveolar lavage (BAL) which has not previously been used in investigating the effect of sulphur dioxide (SO2) on the human lung was performed on 12 subjects before and after controlled chamber exposure with SO2 for 20 minutes. BAL fluid 24 hours after exposure with 10 mg SO2/m3 (4 ppm, 10 subjects) showed increased alveolar macrophage activity as judged by an increase in lysozyme positive macrophages. Twenty four hours after 20 mg/m3 (4 subjects) a further increase was seen, which was accompanied by an increase in total numbers of macrophages and lymphocytes. Seventy two hours after exposure (4 subjects) cell numbers had virtually returned to pre-exposure levels. These previously uninvestigated reactions indicate potentially noxious effects of SO2 in the lungs at exposure levels that are regarded as relatively safe.
在12名受试者于可控实验室内暴露于二氧化硫（SO₂）20分钟之前和之后，进行了支气管肺泡灌洗（BAL），此前该方法未用于研究SO₂对人肺的影响。暴露于10 mg SO₂/m³（4 ppm，10名受试者）24小时后的BAL液显示，通过溶菌酶阳性巨噬细胞数量增加判断，肺泡巨噬细胞活性增强。暴露于20 mg/m³（4名受试者）24小时后，观察到进一步增加，同时巨噬细胞和淋巴细胞总数增加。暴露72小时后（4名受试者），细胞数量几乎恢复到暴露前水平。这些此前未被研究的反应表明，在被视为相对安全的暴露水平下，SO₂对肺部可能存在有害影响。
