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本文引用的文献

1
Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.蛋白激酶CK2控制辅助性T细胞17和调节性T细胞分化之间的命运抉择。
J Immunol. 2017 Jun 1;198(11):4244-4254. doi: 10.4049/jimmunol.1601912. Epub 2017 May 3.
2
Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks.蛋白激酶CK2：调节细胞网络中的复杂关系
Pharmaceuticals (Basel). 2017 Mar 5;10(1):27. doi: 10.3390/ph10010027.
3
CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target.癌症中的CK2：细胞与生化机制及潜在治疗靶点
Pharmaceuticals (Basel). 2017 Jan 28;10(1):18. doi: 10.3390/ph10010018.
4
Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.蛋白激酶CK2通过树突状细胞激活来控制T细胞极化，以响应接触性致敏剂。
J Leukoc Biol. 2017 Mar;101(3):703-715. doi: 10.1189/jlb.3A0715-320RR. Epub 2016 Oct 5.
5
Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.蛋白激酶CK2决定致脑炎性TH17细胞和调节性T细胞发育之间的分子抉择。
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10145-50. doi: 10.1073/pnas.1523869113. Epub 2016 Aug 23.
6
Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.蛋白激酶 CK2 使调节性 T 细胞能够在体内抑制过度的 TH2 反应。
Nat Immunol. 2015 Mar;16(3):267-75. doi: 10.1038/ni.3083. Epub 2015 Jan 19.
7
CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.CD5 依赖性 CK2 激活途径调节 T 细胞失能的阈值。
J Immunol. 2012 Sep 15;189(6):2918-30. doi: 10.4049/jimmunol.1200065. Epub 2012 Aug 17.
8
Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation.蛋白激酶 CK2 是慢性肠道炎症中上皮细胞稳态的关键调节因子。
Mucosal Immunol. 2013 Jan;6(1):136-45. doi: 10.1038/mi.2012.57. Epub 2012 Jul 4.
9
Dynamic protein associations define two phases of IL-1beta transcriptional activation.动态蛋白质相互作用定义了白细胞介素-1β转录激活的两个阶段。
J Immunol. 2008 Jul 1;181(1):503-12. doi: 10.4049/jimmunol.181.1.503.
10
The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development.蛋白激酶CK2的α催化亚基是小鼠胚胎发育所必需的。
Mol Cell Biol. 2008 Jan;28(1):131-9. doi: 10.1128/MCB.01119-07. Epub 2007 Oct 22.

蛋白激酶 CK2：免疫调节的新靶点

Protein Kinase CK2: An Emerging Regulator of Immunity.

机构信息

University of Alabama at Birmingham, Department of Cell, Developmental and Integrative Biology, FOT 1220D, 510 20th Street South, Birmingham, AL 35294-3412, USA.

University of Alabama at Birmingham, Department of Cell, Developmental and Integrative Biology, FOT 1220D, 510 20th Street South, Birmingham, AL 35294-3412, USA.

出版信息

Trends Immunol. 2018 Feb;39(2):82-85. doi: 10.1016/j.it.2017.12.002. Epub 2018 Jan 4.

DOI:10.1016/j.it.2017.12.002
PMID:29307449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5800982/
Abstract

Although it has historically been studied in the context of cancer, recent literature has highlighted the importance of the highly conserved serine/threonine kinase casein kinase II (CK2) in inflammatory disorders. Most strikingly, CK2 is a major regulator of the Th17-Treg axis relevant to many T cell-driven autoimmune disorders including multiple sclerosis (MS).

摘要

尽管 CK2 在癌症研究中具有悠久的历史，但最近的文献强调了高度保守的丝氨酸/苏氨酸激酶酪蛋白激酶 II (CK2) 在炎症性疾病中的重要性。最引人注目的是，CK2 是与许多 T 细胞驱动的自身免疫性疾病（包括多发性硬化症（MS））相关的 Th17-Treg 轴的主要调节剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e9/5800982/03a790b4a96a/nihms928484f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e9/5800982/03a790b4a96a/nihms928484f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e9/5800982/03a790b4a96a/nihms928484f1.jpg