University of Alabama at Birmingham, Department of Cell, Developmental and Integrative Biology, FOT 1220D, 510 20th Street South, Birmingham, AL 35294-3412, USA.
University of Alabama at Birmingham, Department of Cell, Developmental and Integrative Biology, FOT 1220D, 510 20th Street South, Birmingham, AL 35294-3412, USA.
Trends Immunol. 2018 Feb;39(2):82-85. doi: 10.1016/j.it.2017.12.002. Epub 2018 Jan 4.
Although it has historically been studied in the context of cancer, recent literature has highlighted the importance of the highly conserved serine/threonine kinase casein kinase II (CK2) in inflammatory disorders. Most strikingly, CK2 is a major regulator of the Th17-Treg axis relevant to many T cell-driven autoimmune disorders including multiple sclerosis (MS).
尽管 CK2 在癌症研究中具有悠久的历史,但最近的文献强调了高度保守的丝氨酸/苏氨酸激酶酪蛋白激酶 II (CK2) 在炎症性疾病中的重要性。最引人注目的是,CK2 是与许多 T 细胞驱动的自身免疫性疾病(包括多发性硬化症(MS))相关的 Th17-Treg 轴的主要调节剂。