a Institute of Orthopedics , Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA , Beijing , People's Republic of China.
b Academy for Advanced Interdisciplinary Studies , Peking University , Beijing , People's Republic of China.
J Biomater Sci Polym Ed. 2018 Apr;29(5):461-475. doi: 10.1080/09205063.2018.1425180. Epub 2018 Jan 17.
Meniscus is a fibrocartilaginous organ to redistribute stress and enhance the stability of knee joint. Meniscus injury is common and still a formidable challenge to orthopedic surgeons. Surgical techniques and allograft transplantation were primary approaches to meniscus repair, but with intrinsic limitations in clinical practice. Tissue engineering is the most promising method to repair meniscus at present. Electrospinning is a method to fabricate fibers in small scale. With different materials and parameters, electrospinning materials could have different mechanical properties, porosity, and orientation, which could mimic architectural features and mechanical properties of native meniscus. Therefore, electrospinning materials could be used in meniscus regeneration and curing. This review gave a brief introduction of meniscus structure, injury, treatment and the application of electrospinning fibers in meniscus tissue engineering and curing. Besides that, we summarized materials commonly used in electrospinning to fabricate meniscus scaffolds, and discussed the form of electrospinning fibers used such as scaffold, substitute and patch. Finally, the function of electrospinning fibers, for example, carrying drugs, providing mechanical properties were described. The potential applications of electrospinning fibers in meniscus therapy were proposed.
半月板是一种纤维软骨器官，可重新分配关节应力并增强膝关节稳定性。半月板损伤很常见，仍然是骨科医生面临的巨大挑战。手术技术和同种异体移植是半月板修复的主要方法，但在临床实践中存在内在局限性。组织工程是目前修复半月板最有前途的方法。静电纺丝是一种制造小尺寸纤维的方法。通过不同的材料和参数，静电纺丝材料可以具有不同的机械性能、孔隙率和取向，从而模拟天然半月板的结构特征和机械性能。因此，静电纺丝材料可用于半月板再生和修复。本文简要介绍了半月板的结构、损伤、治疗以及静电纺丝纤维在半月板组织工程和修复中的应用。此外，我们总结了常用于静电纺丝制造半月板支架的材料，并讨论了静电纺丝纤维的形式，如支架、替代物和补片。最后，描述了静电纺丝纤维的功能，例如携带药物、提供机械性能。提出了静电纺丝纤维在半月板治疗中的潜在应用。
