Ngadiman Nor Hasrul Akhmal, Noordin M Y, Idris Ani, Kurniawan Denni
1 Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
2 Faculty of Chemical & Energy Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
Proc Inst Mech Eng H. 2017 Jul;231(7):597-616. doi: 10.1177/0954411917699021. Epub 2017 Mar 28.
The potential of electrospinning process to fabricate ultrafine fibers as building blocks for tissue engineering scaffolds is well recognized. The scaffold construct produced by electrospinning process depends on the quality of the fibers. In electrospinning, material selection and parameter setting are among many factors that contribute to the quality of the ultrafine fibers, which eventually determine the performance of the tissue engineering scaffolds. The major challenge of conventional electrospun scaffolds is the nature of electrospinning process which can only produce two-dimensional electrospun mats, hence limiting their applications. Researchers have started to focus on overcoming this limitation by combining electrospinning with other techniques to fabricate three-dimensional scaffold constructs. This article reviews various polymeric materials and their composites/blends that have been successfully electrospun for tissue engineering scaffolds, their mechanical properties, and the various parameters settings that influence the fiber morphology. This review also highlights the secondary processes to electrospinning that have been used to develop three-dimensional tissue engineering scaffolds as well as the steps undertaken to overcome electrospinning limitations.
静电纺丝工艺用于制造超细纤维作为组织工程支架构建单元的潜力已得到广泛认可。通过静电纺丝工艺生产的支架结构取决于纤维的质量。在静电纺丝中，材料选择和参数设置是影响超细纤维质量的众多因素之一，而超细纤维的质量最终决定了组织工程支架的性能。传统静电纺丝支架的主要挑战在于静电纺丝工艺的特性，该工艺只能生产二维静电纺丝垫，从而限制了它们的应用。研究人员已开始专注于通过将静电纺丝与其他技术相结合来制造三维支架结构，以克服这一限制。本文综述了已成功用于静电纺丝制备组织工程支架的各种聚合物材料及其复合材料/共混物、它们的机械性能以及影响纤维形态的各种参数设置。本综述还强调了用于开发三维组织工程支架的静电纺丝后续工艺，以及为克服静电纺丝局限性所采取的步骤。
