Han Jinwang, Song Yanling, Zhu Feng
Department of Neurosurgery, Zhangjiagang Guanghe Chinese and Western Medicine Hospital, Zhangjiagang 215600, Jiangsu, China (Han JW); Department of Burn and Trauma ICU, Changhai Hospital, Naval Medical University, Shanghai 200433, China (Song YL, Zhu F). Corresponding author: Zhu Feng, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018 Jan;30(1):88-90. doi: 10.3760/cma.j.issn.2095-4352.2018.01.017.
Stem cells transfer normal functional mitochondria to injured lung cells and reconstruct their function, which is one of the important mechanisms of stem cells in the treatment of lung injury. Mitochondrial translocation is mediated by intercellular gap junction (GJCs), which is unidirectional. This paper reviewed the research of stem cells for the treatment of lung injury mitochondrial transfer mechanism, to understand the clinical significance of lung mitochondria in physiological and pathological roles of mitochondria and transfer mechanisms of stem cells for the treatment of various types of lung injury.
干细胞将正常功能的线粒体转移至受损肺细胞并重建其功能，这是干细胞治疗肺损伤的重要机制之一。线粒体易位由单向的细胞间缝隙连接（GJCs）介导。本文综述了干细胞治疗肺损伤线粒体转移机制的研究，以了解肺线粒体在生理和病理作用中的临床意义以及干细胞治疗各类肺损伤的转移机制。
