Department of Neurosurgery, Loma Linda University, Loma Linda, California, USA.
Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California, USA.
Stem Cells Dev. 2020 May 1;29(9):555-561. doi: 10.1089/scd.2019.0237. Epub 2020 Feb 24.
Mitochondrial dysfunction is an important pathological process in the setting of ischemic brain injury. Stem cell-mediated mitochondrial transfer provides an efficient intercellular process to supply additional mitochondria in the ischemic brain tissues. In this review, we summarize the mitochondrial pathology associated with brain ischemia, mechanisms of stem cell-mediated mitochondrial transfer, and in vitro/in vivo experimental findings of mitochondrial transfer from stem cells to ischemic vascular endothelial cells/neurons as potential therapeutic strategy in the management of ischemic brain injury.
线粒体功能障碍是缺血性脑损伤的重要病理过程。干细胞介导的线粒体转移提供了一种有效的细胞间过程，可在缺血性脑组织中提供额外的线粒体。在这篇综述中，我们总结了与脑缺血相关的线粒体病理学、干细胞介导的线粒体转移机制，以及干细胞向缺血性血管内皮细胞/神经元转移线粒体的体外/体内实验结果，作为缺血性脑损伤治疗的潜在策略。
