Faria-Urbina Mariana, Oliveira Rudolf K F, Segrera Sergio A, Lawler Laurie, Waxman Aaron B, Systrom David M
1 Division of Pulmonary and Critical Care Medicine, 1861 Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
2 Heart & Vascular Center, Brigham and Women's Hospital, Boston, MA, USA.
Pulm Circ. 2018 Jan-Mar;8(1):2045893218755325. doi: 10.1177/2045893218755325. Epub 2018 Jan 8.
Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VOmax) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO). We speculate that improved pulmonary hemodynamics at maximum exercise "unmasked" a pre-existing skeletal muscle abnormality.
在22例运动性肺动脉高压（ePH）患者中，安立生坦改善了肺血流动力学；然而，最大摄氧量（VOmax）仅呈上升趋势，这是由于最大运动时全身氧摄取（Ca-vO）降低所致。我们推测，最大运动时肺血流动力学的改善“掩盖”了先前存在的骨骼肌异常。
